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FLASH GENE
Symbol MT-ND2 contributors: np/ - updated : 13-03-2006
HGNC name mitochondrially encoded NADH dehydrogenase 2
HGNC id 7456
Corresponding disease
LHON Leber hereditary optic neuropathy
Location mt      Physical location : -
Synonym name
  • complex I ND2 subunit
  • NADH-ubiquinone oxidoreductase chain 2
  • NADH dehydrogenase subunit 2
    • Synonym symbol(s) MTND2, ND2, NAD2, NADH2
    EC.number 1.6.5.3
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Mt-Nd2
    homolog to C.elegans T06G6.1
    Homologene
    FAMILY complex I subunit 2 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalysing reduction of ubiquinone on ubiquinol by NADH in the respiratory chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty one subunits of complex 1, probably in the hydrophobic protein fragment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHON
    Susceptibility to myocardial infarction
    Variant & Polymorphism other haplotype N9B confering resistance against myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS