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FLASH GENE
Symbol MT-CYB contributors: mct/npt - updated : 14-01-2009
HGNC name mitochondrially encoded cytochrome b
HGNC id 7427
Corresponding disease
LHON Leber hereditary optic neuropathy
MTCYB mitochondrial encephalomyopathy
MTMPEI mitochondrial myopathy, with progressive exercice intolerance
Location mt      Physical location : -
Synonym name
  • cytochrome b
  • ubiquinol-cytochrome-c reductase complex cytochrome b subunit
  • cytochrome b-c1 complex subunit 3
  • complex III subunit 3
    • Synonym symbol(s) CYTB, MTCYB, COB, UQCR3
    EC.number 1.10.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome b family, Complex III subunit
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in oxidative phosphorylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTCYB , MTMPEI , LHON
    Susceptibility to severe obesity
    Variant & Polymorphism SNP a G->A transition at position 15497 in severe obesity (rare allele)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS