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FLASH GENE
Symbol MSS51 contributors: mct - updated : 22-05-2019
HGNC name MSS51 mitochondrial translational activator
HGNC id 21000
Location 10q22.3      Physical location : -
Synonym name zinc finger, MYND domain containing 17
Synonym symbol(s) FLJ39565, ZMYND17
DNA
TYPE functioning gene
STRUCTURE 9.98 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2433 - 460 - 2009 19710419
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Zmynd17
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • is a novel, skeletal muscle-specific gene
  • appears to be one of the effectors of TGFB1 and IGF1 on metabolic processes including fatty acid oxidation, glycolysis and oxidative phosphorylation
  • muscle-specific gene, that is a metabolic stress-inducible factor that maintains muscle mitochondrial integrity, with its deficiency profoundly affecting whole-body glucose metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COA1 links the MSS51 post-translational function to COX1 cofactor insertion in cytochrome c oxidase assembly
  • COA3 and COX14 form assembly intermediates with newly synthesized COX1 and are required for MSS51 association with these complexes
  • in addition to affecting MSS51-dependent heme sensing, oxidative stress compromises MSS51 roles in COX1 mRNA processing and translation
  • key target of myostatin and TGFB1 signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • middle-aged mice lacking Zmynd17 exhibited impaired aerobic exercise performance, glucose intolerance, and insulin resistance