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FLASH GENE
Symbol MSN contributors: - updated : 15-11-2004
HGNC name moesin
HGNC id 7373
Location Xq11.21-q12.1      Physical location : 64.887.510 - 64.961.792
Synonym name
  • DNA segment, single copy, probe EST00896
  • membrane-organizing extension spike protein
  • Synonym symbol(s) DXS1117E
    DNA
    TYPE functioning gene
    STRUCTURE 74.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ARHGEF9 Xq11.1 Cdc42 guanine nucleotide exchange factor (GEF) 9 HNRPDP Xq12 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) pseudogene FLJ39827 Xq11.2 hypothetical protein FLJ39827 ASB12 Xq11.2 ankyrin repeat and SOCS box-containing 12 MTMR8 Xq11.2 myotubularin related protein 8 LOC392481 X similar to SHC transforming protein LOC392482 X similar to protein kinase C inhibitor KCIP-1 isoform delta - sheep  (fragment) LOC139281 Xq11.2 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 LOC392483 X similar to hypothetical protein HCA127 Xq12 hepatocellular carcinoma-associated antigen 127 LOC389863 X hypothetical gene supported by BC000228; NM_005077 LOC286449 Xq12 hypothetical gene supported by NM_005077; BC010100 LOC340554 Xq12 similar to KIAA1726 protein FLJ12525 Xq12-q13 hypothetical protein FLJ12525 FKSG43 Xq12 FKSG43 MSN Xq11.21-q12.1 moesin LOC392484 X similar to Nanog homeobox; homeobox transcription factor Nanog LOC347421 Xq12 similar to hypothetical protein FLJ40432 LOC389864 X hypothetical gene supported by AK091520; BC006550; BC007435; NM_002139 LOC389865 X LOC389865 Z39IG Xp11-q11 Homo sapiens Ig superfamily protein (Z39IG), mRNA. LOC392485 X similar to CG13379-PA LOC139272 Xq12 similar to eukaryotic initiation factor 4B HEPH Xq11-q12 hephaestin LOC392486 X similar to Probable G protein-coupled receptor GPR83 precursor LOC139270 Xq12 similar to Pyruvate kinase, M1 isozyme (Pyruvate kinase muscle isozyme) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1) XEDAR Xp22 similar to Pyruvate kinase, M1 isozyme (Pyruvate kinase muscle isozyme) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1) AR Xq11.21-q12.1 androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentralwhite matter  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text vascular endothelial cells in developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal FERM (EPB41,ezrin,radixin,moesin) domain
  • cysteine-rich, basic charged globular module
  • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/moesin/radixin-like moesin (ERM) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • filopodial protein involved in cell recognition
  • cell movement and morphological changes
  • membrane-organizing extension spike protein
  • developmentally regulated and abundantly expressed in germinal matrix and/or migrating cells during cerebral cortical development
  • clustering in an endothelial actin rich docking structure with ICAM1, VCAM1, EZR
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text downstream effector of trafficking PRKC-integrin complex involved in the control of cell motility
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F-actin binding
  • interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS