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FLASH GENE
Symbol MSN contributors: mct - updated : 13-09-2017
HGNC name moesin
HGNC id 7373
Corresponding disease
IMD50 Immunodeficiency 50
Location Xq12      Physical location : 64.887.510 - 64.961.792
Synonym name
  • DNA segment, single copy, probe EST00896
  • membrane-organizing extension spike protein
    • Synonym symbol(s) DXS1117E, HEL70, IMD50
    DNA
    TYPE functioning gene
    STRUCTURE 153.55 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3981 - 577 - 1995 7628534
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentralwhite matter  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Nervousglia
    NervousSchawnn cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text vascular endothelial cells in developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal FERM (EPB41,ezrin,radixin,moesin) domain
  • cysteine-rich, basic charged globular module
  • a C-terminal actin-binding domain
    • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/moesin/radixin-like moesin (ERM) family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes to the centrosomes and mitotic spindle during mitosis
  • in a small fraction of cells and at a low level, MSN can be detected in interphase nuclei in regions complementary to the chromatin, and its level rapidly increases during prophase and it co-localizes with the actin network surrounding the mitotic spindles throughout mitosis (pMID: 19595131)
    • basic FUNCTION
  • filopodial protein involved in cell recognition
  • cell movement and morphological changes
  • membrane-organizing extension spike protein
  • developmentally regulated and abundantly expressed in germinal matrix and/or migrating cells during cerebral cortical development
  • clustering in an endothelial actin rich docking structure with ICAM1, VCAM1, EZR
  • importance of the MSN-induced increase in cortical rigidity for spindle morphogenesis and orderly chromosome segregation
  • spatiotemporal control of MSN activation at the mitotic cortex provides localized cues to coordinate cortical contractility and microtubule interactions during cell division
  • overactivation of MSN at the polar cortex impairs cell elongation and thus cytokinesis
  • changes in the phosphorylation levels of NF2 and MSN lead likely to changes in epithelial organization
  • ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton.
  • its upregulation influences extra-centrosome behavior and robust bipolar spindle formation
    • cyte Leukocyte transendothelial migration (TEM)
  • is involved in nuclear mRNA export
  • cytoskeletal adaptor protein that plays an important role in modification of the actin cytoskeleton
  • critical role for MSN in both neuronal morphogenesis and long-term memory formation
  • supportive role of EZR, RDX, MSN in cortical activities during cytokinesis
  • EZR and MSN play mutually exclusive roles in modulating SELL signalling and shedding to control protrusion dynamics and polarity during monocyte transendothelial migration (TEM)
  • ERM proteins, EZR, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures
    • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text downstream effector of trafficking PRKC-integrin complex involved in the control of cell motility
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds to and stabilizes microtubules at the cell cortex
    • protein
  • F-actin binding
  • interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
  • P2RX7 stimulation triggers the phosphorylation of EZR/RDX/MSN, which translocate to the plasma membrane where they associate with P2RX7
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • inhibition of cell adhesion by phosphorylated EZR/RDX/MSN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma cells correlated with increases in cell proliferation, invasion and migration, suggesting moesin role in glioblastoma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS