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FLASH GENE

Symbol

MSL3

contributors: mct - updated : 17-06-2011

HGNC name	male-specific lethal 3 homolog (Drosophila)
HGNC id	7370

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp22.3      Physical location : 11.776.277 - 11.793.870
Synonym name	male-specific lethal-3 (Drosophila)-like 1
	MSL3-like 1
	Drosophila MSL3-like 1
Synonym symbol(s)	DKFZP586J1822, MSL3L1

DNA

TYPE	functioning gene
STRUCTURE	17.60 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_078629 13 splicing 2359 59.8 521 - 1999 10395802 MSL3L1 Isoform b 12 splicing 2260 53 462 - 1999 10395802 lack exon 2 NM_006800 12 splicing 2331 - 355 - 1999 10395802 lack exon 1 NM_078628 9 - 3564 47.9 416 - 1999 10395802 NM_001193270 - - 2337 - 509 - 1999 10395802

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two chromo domain : one at the N, the other at the C terminus
	a canonical methyllysine binding pocket made up of residues Tyr-31, Phe-56, Trp-59, and Trp-63
	a highly conserved N-terminal chromo-barrel domain (CBD) (residues 2–91
	a conserved C-terminal MRG domain (residues 196–512) , responsible for interactions with MSL1, but does not interact directly with MYST1

HOMOLOGY

interspecies

homolog to Drosophila male-specific lethal 1

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	role in chromatin remodeling and transcription regulation
	essential for cell viability
	plays an important role in targeting the male specific lethal complex to chromatin in both humans and flies by binding to H4K20Me(1)
	may help to target the MSL complex to specific chromatin regions at least in part by binding to H4K20Me1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark

INTERACTION

DNA

RNA

small molecule

protein	MSL1 interacts with MSL3 as an extended chain forming an extensive hydrophobic interface
	interact directly with MYST1 via its conserved C-terminal MRG domain

cell & other

REGULATION

Other

MSL function is regulated by a combination of post-translational modifications

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS