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FLASH GENE

Symbol

MSC

contributors: mct - updated : 07-03-2007

HGNC name	musculin (activated B-cell factor-1)
HGNC id	7321

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q21.1-q21.2      Physical location : 72.753.776 - 72.756.731
Genatlas name	activated B-cell factor 1
Synonym symbol(s)	ABF1, MYOR, ABF-1

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive female system placenta     highly Respiratory lung         Skin/Tegument skin       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage
cell lines	EBV immortalized lymphoblastoid cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	basic helix-loop-helix (HLH) with transcription inhibition domain,
	putative nuclear localization signal (NLS),
	a glycine rich region
	a stretch of acidic residues

HOMOLOGY

interspecies

homolog to murine Musculin

Homologene

FAMILY

basic helix-loop-helix family of transcription factor

CATEGORY

immunity/defense , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	maybe involved in regulating antigen-dependent B cell differentiation
	nuclear transcriptional repressor
	may play important roles not only in developmental processes but also in regenerative processes in adult tissue
	may be involved in rapid down-regulation of MYOD1 in muscle regeneration

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

signal transduction

downstream target of the B cell receptor/signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

ID2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in acute renal failure

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS