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FLASH GENE
Symbol MS4A4E contributors: - updated : 01-09-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 4E
HGNC id 14284
Location 11q12      Physical location : -
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 23.00 kb     7 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane domains
  • N and C terminal cytoplasmic regions
  • HOMOLOGY
    interspecies homolog to murine Ms4a2
    intraspecies homolog to MS4A4A
    Homologene
    FAMILY MS4A family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS