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FLASH GENE
Symbol MRVI1 contributors: - updated : 03-07-2006
HGNC name murine retrovirus integration site 1 homolog
HGNC id 7237
Location 11p15      Physical location : 10.594.637 - 10.715.535
Synonym name
  • inositol 1,4,5-triphosphate associated CGMP kinase substrate
  • IP3R-associated cGMP kinase substrate
  • JAW1-related protein
  • Synonym symbol(s) IRAG, JAW1L
    DNA
    TYPE virus associated
    STRUCTURE 118.00 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    SCUBE2 11p15.3 signal peptide, CUB domain, EGF-like 2 FLJ46111 11p15.3 FLJ46111 protein RAB6IP1 11p15.3 RAB6 interacting protein 1 KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin LOC338749 11p15.3 hypothetical LOC338749 AMPD3 11p15 adenosine monophosphate deaminase (isoform E) RNF141 11p15.3 ring finger protein 141 XLKD1 11p15 extracellular link domain containing 1 MRVI1 11p15 murine retrovirus integration site 1 homolog SH2BP1 11pter-p15.4 SH2 domain binding protein 1 (tetratricopeptide repeat containing) EIF4G2 11p15 eukaryotic translation initiation factor 4 gamma, 2 LOC58486 11p15.3 transposon-derived Buster1 transposase-like protein MGC71806 11p15.3 similar to Hypothetical protein LOC233733 USP47 11p15.2 ubiquitin specific protease 47 RIG 11p15.1 ubiquitin specific protease 47 DKK3 11p15.2 dickkopf homolog 3 (Xenopus laevis)
    RNA
    TRANSCRIPTS type untranslated
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3396 - 892 - Casteel
    - - 3499 - 803 - Casteel
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    cell lineage
    cell lines myeloid leukemias BXH2
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine retrovirus integration site 1
    intraspecies homolog to Jaw1 a lymphoid restricted type II membrane protein that localizes to endoplastic reticulum
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION may be a myeloid leukemia tumor suppressor gene
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS