basic FUNCTION
| B plays a critical role in regulating differentiation of cardiac neural crest cells into smooth muscle and demonstrate that neural crest-derived smooth muscle differentiation is specifically required for normal cardiovascular morphogenesis |
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has a unique role in regulating smooth muscle genes important for liver, yolk sac, and portal vascular development |
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vplay a role in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation and in the pathogenesis of congenital heart disease and vascular proliferative syndromes |
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increase the expression levels of actin cytoskeletal proteins via serum response factor, thereby triggering reorganization of the actin cytoskeleton |
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important mediators of TGF-beta1-induced epithelial-mesenchymal transition |
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with MKL1, are co-activators for serum response factor (SRF) |
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(plays a role in megakaryocyte maturation |
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MKL1 and MKL2 have both SRF-dependent and SRF-independent activity in megakaryocytopoiesis |
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regulates a conserved TGFB1 signaling pathway that is required for angiogenesis and ultimately embryonic survival |
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MKL1, MKL2 are required for accurate cell cycle progression and maintenance of genomic stability in fibroblast cells |
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redundant but essential roles of MKL1, MKL2 in maintenance of cardiac structure and function and as indispensible links in cardiac cytoskeletal gene regulatory networks |