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FLASH GENE
Symbol MRPS22 contributors: mlc - updated : 05-01-2008
HGNC name mitochondrial ribosomal protein S22
HGNC id 14508
Corresponding disease
TCOH tubulopathy, cardiomyopathy, skin oedema, hypotonia
Location 3q23      Physical location : 139.062.860 - 139.075.885
Synonym name
  • chromosome 3 open reading frame 5
  • Synonym symbol(s) GIBT, GK002, C3orf5, RPMS22, MRP-S22
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure 3 CPG islands
    MAPPING cloned Y linked N status provisional
    Physical map
    NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1155 - 360 - Ewing (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to E.Coli 30S subunit proteins
    Homologene
    FAMILY ribosomal protein S22P family
    CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • specific to mitochondria ribosomes
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small subunit (28S) of the mitochondrial ribosome, including two RNA molecules and 78 MRPs among which 31 proteins for the small subunit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TCOH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS