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Symbol MRPS2 contributors: mct - updated : 22-05-2018
HGNC name mitochondrial ribosomal protein S2
HGNC id 14495
Corresponding disease
COXPD36 combined oxidative phosphorylation deficiency 36
Location 9q34.3      Physical location : 138.392.482 - 138.396.518
Synonym name mitochondrial 28S ribosomal protein S2
Synonym symbol(s) CGI-91, MRP-S2, S2mt, COXPD36
DNA
TYPE functioning gene
STRUCTURE 4.68 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389804 9 LOC389804 LOC392397 9 similar to hypothetical protein FCN2 9q34 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) FCN1 9q34 ficolin (collagen/fibrinogen domain containing) 1 OLFM1 9q34.3 olfactomedin 1 LOC392398 9 similar to ligand-independent activating molecule for estrogen receptor C9orf62 9q34.3 chromosome 9 open reading frame 62 KIAA0649 9q34.3 chromosome 9 open reading frame 62 MGC29761 9q34.3 hypothetical protein MGC29761 MRPS2 9q34 mitochondrial ribosomal protein S2 LCN1 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) OBP2A 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) PAEP 9q34.2-q34.3 progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein) LOC138159 9q34.3 beta-lactoglobulin pseudogene GLTDC1 9q34.3 galactosyltransferase family 6 domain containing 1 LOC392399 9 similar to Putative MUP-like lipocalin precursor LOC286220 9q34.3 hypothetical protein LOC286220 KCNT1 9q34.3 potassium channel, subfamily T, member 1 CAMSAP1 9q34.3 calmodulin regulated spectrin-associated protein 1 LOC389805 9 similar to 9530003A05 protein GBDR1 9q34.1-q34.3 similar to 9530003A05 protein BTBD14A 9q34.3 BTB (POZ) domain containing 14A LOC392400 9 similar to F4N2.10 LOC389806 9 hypothetical gene supported by BC009060 LOC389807 9 LOC389807 LOC389808 9 LOC389808
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1516 33 296 - 2001 11279123
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to E.Coli 30S subunit proteins
homolog to C.elegans Mrps2
homolog to Drosphila Mrps2
homolog to yeast S.cerevisiae Mrps2
ortholog to bacterial bS2
Homologene
FAMILY
  • ribosomal protein S2P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • in contrast to MRPS11, MRPS2 is able to assemble into a rapidly sedimenting particle to a significant extent in the absence of either MRPS16 or MRPS22
  • plays likely an important but currently unclear role in mitoribosomal biogenesis or function
  • structural role for MRPS2 in the connection of different domains of the mitochondrial ribosome
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small subunit (28S) of the mitochondrial ribosome, including two RNA molecules and 78 MRPs among which 31 proteins for the small subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS