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FLASH GENE
Symbol MRPS12 contributors: KTN - updated : 28/11/2008
HGNC name mitochondrial ribosomal protein S12
HGNC id 10380
Location 19q13.2      Physical location : 39.421.347 - 39.423.657
Synonym symbol(s) RPMS12, RPS12, MPR-S12, RPSM12, MT-RPS12
DNA
TYPE functioning gene
STRUCTURE 2.31 kb     5 Exon(s)    single Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D19S287 - MRPS12 - D19S220 - qter
Authors Shah (98)
RNA
TRANSCRIPTS type messenger
text
  • all variants encode the same protein
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1116 - 138 - Johnson
  • donor site 1A-297nt, acceptor -19nt
  • a 109 aa mature peptide of 12.1 kda
  • differing in the 5' UTR compared to variant 1
  • 2 splicing 1094 - 138 ubiquitous Johnson
  • shorter 5'utr
  • a 109 aa mature peptide of 12.1 kda
  • 3 splicing 991 - 138 ubiquitous Johnson
  • containing a shorter 5' UTR when compared to variant 1
  • a 109 aa mature peptide of 12.1 kda
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestine   moderately
     liver    
     salivary gland   moderately
    Endocrinepancreas   predominantly
    Lymphoid/Immunelymph node    
     tonsils   highly
    Reproductivefemale systemuterus  moderately
     male systemprostate  moderately
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prepeptide processed to a peptide of 112 aa, signature motif (R, K)-x-P-N-S-(A, R)-x-R
  • HOMOLOGY
    interspecies homolog to chimpanzee MRPS12 (99.3 pc)
    homolog to dog MRPS12 (82.1 pc)
    homolog to cow MRPS12 (83.3 pc)
    homolog to rattus Mrps12 (87 pc)
    homolog to murine Mrps12 (85.5 pc)
    Homologene
    FAMILY
  • ribosomal protein S12P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text mitochondrial ribosome
    basic FUNCTION
  • controling the accuracy of decoding
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small subunit (28S) of the mitochondrial ribosome, including two RNA molecules and 78 MRPs among which 31 proteins for the small subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other downregulated in response to serum starvation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • candidate gene for susceptibility to aminoglycoside ototoxicity
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS