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FLASH GENE
Symbol MRPL53 contributors: KTN - updated : 07-01-2009
HGNC name mitochondrial ribosomal protein L53
HGNC id 16684
Location 2p13.1      Physical location : 74.699.109 - 74.699.927
Synonym symbol(s) FLJ90728, MGC20402
DNA
TYPE functioning gene
STRUCTURE 0.82 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MGC10955 2p13.1 hypothetical protein MGC10955 LOC388962 2 similar to RIKEN cDNA 1810056O20 C2orf6 2p12 chromosome 2 open reading frame 6 MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin HMGA1L4 2p13.1 high mobility group AT-hook 1-like 4 WBP1 2p12 WW domain binding protein 1 GCS1 2p13 WW domain binding protein 1 MRPL53 2p13.1 mitochondrial ribosomal protein L53 LOC151534 2p13.1 hypothetical protein BC009264 FLJ14397 2p13.1 hypothetical protein FLJ14397 FLJ12788 2p13.1 hypothetical protein FLJ12788 NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3 DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 616 12 112 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Digestiveintestine   moderately
 pancreas exocrine   moderately
 salivary gland   moderately
Endocrineneuroendocrinepituitary  moderately
 parathyroid   predominantly
 thyroid   moderately
Lymphoid/Immunetonsils   moderately
Reproductivefemale systembreastmammary gland highly
 male systemprostate  moderately
Urinarykidney   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
interspecies homolog to dog MRPL53 (92 pc)
homolog to chimpanzee MRPL53 (99.1 pc)
homolog to cow MRPL53 (92 pc)
homolog to rattus Mrpl53 (86.2 pc)
homolog to murine Mrpl53 (88 pc)
Homologene
FAMILY
CATEGORY regulatory , structural protein , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
text
  • mitochondrial ribosome
  • basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large subunit of the mitochondrial ribosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS