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FLASH GENE

Symbol

MRPL4

contributors: - updated : 16-12-2005

HGNC name	mitochondrial ribosomal protein L4
HGNC id	14276

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 10.362.639 - 10.370.734
Synonym symbol(s)	CGI-28, L4mt, MGC2681, MGC16367

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MRPL4 v1 - splicing 1511 - 311 - Suzuki MRPL4 v2 - splicing 1375 - 311 - Suzuki MRPL4 v3 - - 2404 - 263 - Suzuki

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to chimpanzee LOC455697
	ortholog to murine Mrpl4
	ortholog to rattus mrpl4

Homologene

FAMILY

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	mitochondrial ribosome

basic FUNCTION	mitochondrial proteins biosynthesis
	ribosomal structure and biogenesis

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least,70 MRPs among which 47 proteins for the large subunit

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS