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FLASH GENE
Symbol MRPL4 contributors: - updated : 16-12-2005
HGNC name mitochondrial ribosomal protein L4
HGNC id 14276
Location 19p13.2      Physical location : 10.362.639 - 10.370.734
Synonym symbol(s) CGI-28, L4mt, MGC2681, MGC16367
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC162993 19p13.2 hypothetical protein LOC162993 UBE2L4 19q13.1-q13.2 ubiquitin-conjugating enzyme E2L 4 FBXL12 19p13.2 F-box and leucine-rich repeat protein 12 PIN1 19p13.2 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 UBL5 19p13.3 ubiquitin-like 5 LOC390888 19 similar to 60S ribosomal protein L10 (QM protein homolog) OLFM2 19p13.2 olfactomedin 2 COL5A3 19p13.2 collagen, type V, alpha 3 RDH8 19p13.2-p13.3 retinol dehydrogenase 8 (all-trans) LOC388502 19 similar to Complement C3 precursor LOC388503 19 similar to Complement C3-1 LOC147740 19p13.2 similar to complement C3 protein (GPC3) precursor FLJ11286 19p13.2 hypothetical protein FLJ11286 ANGPTL6 19p13.2 angiopoietin-like 6 PPAN 19p13 peter pan homolog (Drosophila) P2RY11 19p13.2 purinergic receptor P2Y, G-protein coupled, 11 EIF3S4 19p13.2 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa DNMT1 19p13.2 DNA (cytosine-5-)-methyltransferase 1 EDG5 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 LOC388504 19 LOC388504 MRPL4 19p13.2 mitochondrial ribosomal protein L4 ICAM1 19p13.3-p13.2 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM4 19p13.2-cen intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM5 19p13.2 intercellular adhesion molecule 5, telencephalin LOC388505 MGC19604 19p13.2 similar to RIKEN cDNA B230118G17 gene RAVER1 19p13.2 RAVER1 ICAM3 19p13.3-p13.2 intercellular adhesion molecule 3 TYK2 19p13.2 tyrosine kinase 2 CDC37 19p13.2 CDC37 cell division cycle 37 homolog (S. cerevisiae) PDE4A 19p13.2 phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) KEAP1 19p13.2 kelch-like ECH-associated protein 1 EDG8 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 AUTL4 19p13.2 AUT-like 4, cysteine endopeptidase (S. cerevisiae) FLJ12949 19p13.2 hypothetical protein FLJ12949 CDKN2D 19p13.2 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) AP1M2 19p13.2 adaptor-related protein complex 1, mu 2 subunit CTL2 19p13.1 adaptor-related protein complex 1, mu 2 subunit ILF3 19p13 interleukin enhancer binding factor 3, 90kDa QTRT1 19p13.3 queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) DNM2 19p13.2 dynamin 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1511 - 311 - Suzuki
- splicing 1375 - 311 - Suzuki
- - 2404 - 263 - Suzuki
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to chimpanzee LOC455697
ortholog to murine Mrpl4
ortholog to rattus mrpl4
Homologene
FAMILY
CATEGORY structural protein , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
text mitochondrial ribosome
basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least,70 MRPs among which 47 proteins for the large subunit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS