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FLASH GENE
Symbol MRPL32 contributors: - updated : 16-11-2005
HGNC name mitochondrial ribosomal protein L32
HGNC id 14035
Location 7p14      Physical location : 42.971.938 - 42.977.451
Synonym symbol(s) L32mt, HSPC283
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TAS2R39 7q35 taste receptor, type 2, member 39 TAS2R40 7q35 taste receptor, type 2, member 40 LOC51064 7q35 glutathione S-transferase subunit 13 homolog FLJ90586 7q35 hypothetical protein FLJ90586 CASP2 7q34-q35 caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2) LOC393035 7 similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) CLCN1 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) KIAA0773 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) LOC392833 7 LOC392833 ZYX 7q34-q35 zyxin EPHA1 7q32-q34 EphA1 LOC168283 7p13 similar to T-complex protein 1, alpha subunit (TCP-1-alpha) (CCT-alpha) TAS2R60 7q35 taste receptor, type 2, member 60 TAS2R41 7q35 taste receptor, type 2, member 41 LOC393036 7 similar to olfactory receptor MOR257-1 LOC393037 7 similar to seven transmembrane helix receptor C7orf25 7p14-p11.2 chromosome 7 open reading frame 25 PSMA2 7p13 proteasome (prosome, macropain) subunit, alpha type, 2 LOC393038 7 similar to 60S ribosomal protein L26 MRPL32 7p14 mitochondrial ribosomal protein L32 KIAA0322 7p22 mitochondrial ribosomal protein L32 LOC393039 7 similar to 60S ribosomal protein L26 LOC393040 7 similar to Multifunctional protein ADE2 FLJ40722 7q35 hypothetical protein FLJ40722 MGC41943 7q35 hypothetical protein MGC41943 LOC393041 7 similar to Multifunctional protein ADE2 LOC393042 7 similar to 60S ribosomal protein L26 KIAA0738 7q35 similar to 60S ribosomal protein L26 STK17A 7p14-p12 serine/threonine kinase 17a (apoptosis-inducing) LOC393043 7 similar to Olfactory receptor 2F2 (Olfactory receptor 7-1) (OR7-1) FLJ10803 7p13 hypothetical protein FLJ10803
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to E Coli, Drosophila, C Elegans, S Cerevisiae mitochondrial ribosomal protein
Homologene
FAMILY
CATEGORY structural protein , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
text mitochondrial ribosome, protein associated with the inner membrane
basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • cells lacking MRPL32 are respiratory incompetent
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 proteins among which 47 proteins for the large subunit
  • INTERACTION
    DNA
    RNA mRNAs
    small molecule
    protein interacting with SPG7
    cell & other
    REGULATION
    Other maturation of MRPL32 depends on proteolysis by the m-AAA protease
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS