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FLASH GENE
Symbol MRPL32 contributors: - updated : 16-11-2005
HGNC name mitochondrial ribosomal protein L32
HGNC id 14035
Location 7p14      Physical location : 42.971.938 - 42.977.451
Synonym symbol(s) L32mt, HSPC283
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to E Coli, Drosophila, C Elegans, S Cerevisiae mitochondrial ribosomal protein
Homologene
FAMILY
CATEGORY structural protein , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
text mitochondrial ribosome, protein associated with the inner membrane
basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • cells lacking MRPL32 are respiratory incompetent
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 proteins among which 47 proteins for the large subunit
  • INTERACTION
    DNA
    RNA mRNAs
    small molecule
    protein interacting with SPG7
    cell & other
    REGULATION
    Other maturation of MRPL32 depends on proteolysis by the m-AAA protease
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS