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FLASH GENE
Symbol MRPL21 contributors: mct - updated : 07-03-2019
HGNC name mitochondrial ribosomal protein L21
HGNC id 14479
Location 11q13.3      Physical location : 68.658.746 - 68.671.303
Synonym symbol(s) L21mt, MRP-L21
DNA
TYPE functioning gene
STRUCTURE 12.56 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 713 - 205 - 2002 11943462
  • isoform d
    • - splicing 659 - 187 - 2002 11943462
    lacking an in frame internal segment
    - splicing 794 - 150 - 2002 11943462
    different site resulting in frameshift and early codon stop
    7 splicing 726 - 120 - 2002 11943462
    differnt splice site in the 5'utr
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to E Coli (50S), Drosophila, C Elegans, S Cerevisiae mitochondrial ribosomal protein
    Homologene
    FAMILY
    CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • TEAD1 may mediate muscle development through its target genes, MRPL21, NDUFA6 and CCNE1
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 MRPs among which 47 proteins for the large subunit
    INTERACTION
    DNA
    RNA mRNAs
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS