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FLASH GENE
Symbol MRPL10 contributors: mct/npt - updated : 24-06-2010
HGNC name mitochondrial ribosomal protein L10
HGNC id 14055
Location 17q21.32      Physical location : 45.900.638 - 45.908.903
Synonym name 39S ribosomal protein L10, mitochondrial
Synonym symbol(s) RPML8, MRP-L8, MGC17973, L10MT, MRP-L10
DNA
TYPE functioning gene
STRUCTURE 8.27 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GOSR2 17q21 golgi SNAP receptor complex member 2 LOC388394 17 similar to RIKEN cDNA 2410012A13 LOC388395 17 similar to Hypothetical protein KIAA0563 LOC388396 17 similar to KIAA0563 protein LOC388397 17 LOC388397 CDC27 17q21.3 cell division cycle 27 MYL4 17q21.2 myosin, light polypeptide 4, alkali; atrial, embryonic ITGB3 17q21.31 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1848 - 271 - -
an additional exon, distinct N terminus from isoform a
5 - 1750 - 261 - Kenmochi (2001)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • first 148 AAs of the N-terminal domain are sufficient for binding SIRT3 (Yang 2010)
  • HOMOLOGY
    interspecies ortholog to E Coli (50S), Drosophila, C elegans, S cerevisiae mitochondrial ribosomal protein
    Homologene
    FAMILY
  • ribosomal protein L10P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,ribosome
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • major acetylated protein in the mitochondrial ribosome (Yang 2010)
  • reversible acetylation of MRPL10 regulating mitochondrial protein synthesis (Yang 2010)
  • novel substrate of the NAD+-dependent deacetylase, SIRT3 (Yang 2010)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 MRPs among which 47 proteins for the large subunit
    INTERACTION
    DNA
    RNA mRNAs
    small molecule
    protein
    cell & other
    REGULATION
    Other deacetylation by SIRT3 of MRPL10 in an NAD+-dependent manner (Yang 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS