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FLASH GENE
Symbol MRPL10 contributors: mct/npt - updated : 24-06-2010
HGNC name mitochondrial ribosomal protein L10
HGNC id 14055
Location 17q21.32      Physical location : 45.900.638 - 45.908.903
Synonym name 39S ribosomal protein L10, mitochondrial
Synonym symbol(s) RPML8, MRP-L8, MGC17973, L10MT, MRP-L10
DNA
TYPE functioning gene
STRUCTURE 8.27 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1848 - 271 - -
an additional exon, distinct N terminus from isoform a
5 - 1750 - 261 - Kenmochi (2001)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • first 148 AAs of the N-terminal domain are sufficient for binding SIRT3 (Yang 2010)
  • HOMOLOGY
    interspecies ortholog to E Coli (50S), Drosophila, C elegans, S cerevisiae mitochondrial ribosomal protein
    Homologene
    FAMILY
  • ribosomal protein L10P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,ribosome
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • major acetylated protein in the mitochondrial ribosome (Yang 2010)
  • reversible acetylation of MRPL10 regulating mitochondrial protein synthesis (Yang 2010)
  • novel substrate of the NAD+-dependent deacetylase, SIRT3 (Yang 2010)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 MRPs among which 47 proteins for the large subunit
    INTERACTION
    DNA
    RNA mRNAs
    small molecule
    protein
    cell & other
    REGULATION
    Other deacetylation by SIRT3 of MRPL10 in an NAD+-dependent manner (Yang 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS