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FLASH GENE
Symbol MRGPRX2 contributors: mct - updated : 07-12-2011
HGNC name MAS-related GPR, member X2
HGNC id 17983
Location 11p15.1      Physical location : 19.076.004 - 19.082.228
Synonym name
  • G protein-coupled receptor MRGX2
  • Synonym symbol(s) MRGX2
    DNA
    TYPE functioning gene
    STRUCTURE 6.23 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2130 - 330 - 2009 19531482
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
     gangliasensory gangliadorsal root highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiensAdult
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY G-protein coupled receptor 1 family, Mas subfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cortistatin receptor, may be regulating
  • nociceptor function and/or development, including the sensation or modulation of pain
  • involved in nociception
  • G protein-coupled receptor for the antibacterial peptide CAMP and, unlike most G protein-coupled receptors it is resistant to agonist-induced receptor phosphorylation, desensitization, and internalization
  • MRGPRX2 is a novel GPCR for CAMP in human mast cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cortistatin receptor
  • is resistant to CAMP-induced receptor phosphorylation, desensitization, and internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS