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FLASH GENE
Symbol MRGBP contributors: mct - updated : 31-01-2017
HGNC name MRG domain binding protein
HGNC id 15866
Location 20q13.33      Physical location : -
Synonym name
  • MRG-binding protein
  • MRG(MORF4-related gene)-binding protein
  • chromosome 20 open reading frame 20
  • up-regulated in colon cancer 4
  • Synonym symbol(s) FLJ10914, MRG15BP, Eaf7, URCC4, C20orf20
    DNA
    TYPE functioning gene
    STRUCTURE 5.33 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2845 22.3 204 - 2003 12963728
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • has an important function in proliferation of cancer cells through the regulation of BRD8
  • contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells
  • shares little sequence and structural similarity with PHF12, yet targets similar pockets on the surface of the MRG domain, mimicking PHF12 in its interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of TRRAP/TIP60-containing histone acetyltransferase complex
  • member of the KAT5/NuA4 histone acetyltransferase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MORF4L1 and MORF4L2 proteins are MRGBP-associating proteins
  • MRFAP1 may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of colorectal tumors, and the enhanced expression was associated with cell proliferation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    should be a novel therapeutic target for colorectal cancer
    ANIMAL & CELL MODELS