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FLASH GENE
Symbol MRAS contributors: mct/npt - updated : 08-06-2009
HGNC name muscle RAS oncogene homolog
HGNC id 7227
Location 3q22.3      Physical location : 138.066.624 - 138.124.376
Synonym name
  • muscle and microspikes RAS
  • Ras-related protein R-Ras3
  • Synonym symbol(s) M-RAs, R-RAS3, RRAS3, FLJ42964
    DNA
    TYPE functioning gene
    STRUCTURE 57.75 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    STAG1 3q22-q24 stromal antigen 1 MGC3295 3q22.3 hypothetical protein MGC3295 NCK1 3q21 NCK adaptor protein 1 MGC34923 3q22.3 hypothetical protein MGC34923 NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4013 23.7 208 - Erdmann (2009)
    6 - 4454 23.7 208 - Erdmann (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text moderately in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain
  • a prenylation motif
  • a C-terminal membrane localization domain
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Mras (97.1 pc)
    homolog to murine Mras (96.2 pc)
    intraspecies homolog to RRAS2
    Homologene
    FAMILY
  • GTP-binding superfamily
  • RAS subfamily
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text lipid-anchor on the cytoplasmic side
    basic FUNCTION
  • implicated in neuronal differentiation via the MAPK cascade
  • may be involved in growth-factor signal transduction
  • acting as a GTPase
  • may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation
  • activating weakly the MAP kinase pathway
  • playing a role for in adhesion signaling, which is important in the atherosclerotic process (Erdmann 2009)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • actin cytoskeleton organization and biogenesis
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interacting weakly with Raf and RalGDS
  • RAPH1 is a novel effector of MRAS in dendrites
  • SEMA4D/PLXNB1-mediated MRas GAP activity regulates actin-based dendrite remodeling through RAPH1
  • cell & other
    REGULATION
    activated by NGF
    induced by IL9, in a dependent manner of the JAK/STAT pathway
    Other oncogenically activated in some tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to coronay artery disease
    Variant & Polymorphism SNP SNP rs9818870, in the 3' UTR of MRAS in close proximity to a cluster of miRNA binding sites, associated with coronary artery disease (Erdmann 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS