Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MPZL1 contributors: mct/npt - updated : 04-07-2008
HGNC name myelin protein zero-like 1
HGNC id 7226
Location 1q23.3      Physical location : 167.691.186 - 167.761.155
Synonym name
  • myelin protein zero-like protein MPZL1b
  • protein zero-related
  • immunoglobulin family transmembrane protein
  • Synonym symbol(s) PZR, FLJ21047, PZR1b, PZRa, PZRb, FLJ21047
    DNA
    TYPE functioning gene
    STRUCTURE 68.00 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC284684 1q23.2 similar to cDNA sequence BC004853 LOC391125 1 similar to ribosomal protein S2; 40S ribosomal protein S2 MGST3 1q23 microsomal glutathione S-transferase 3 ALDH9A1 1q22-q23 aldehyde dehydrogenase 9 family, member A1 LOC54499 1q22-q25 putative membrane protein LOC391126 1 similar to 60S ribosomal protein L26 UMPK 1p34.1-p33 uridine monophosphate kinase LOC391127 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC149297 1q23.3 similar to RIKEN cDNA C030014K22 gene LOC284685 1q23.3 similar to Ewing sarcoma breakpoint region 1 isoform EWS LOC391128 1 similar to hypothetical protein 4831428F09 LOC116123 1q23.3 hypothetical protein BC014341 LOC391129 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 POGK 1q23.2 pogo transposable element with KRAB domain STAF42 1q23.3 SPT3-associated factor 42 LOC388712 1 similar to dJ782G3.1 (LISCH7 (liver-specific BHLH-ZIP transcription factor)) FLJ14904 1q23.3 hypothetical protein FLJ14904 GPA33 1q23.2 glycoprotein A33 (transmembrane) LOC92235 1q22-q24 hypothetical cardiac/skeletal muscle-expressed ORF LOC391130 1 similar to ribosomal protein S17 POU2F1 1q22-q23 POU domain, class 2, transcription factor 1 CD3Z 1q22-q23 CD3Z antigen, zeta polypeptide (TiT3 complex) SRD5BP1 1q23-q25 steroid-5-beta-reductase, beta polypeptide pseudogene 1 CREG 1q24 cellular repressor of E1A-stimulated genes MGC21854 1q22-q24 hypothetical protein MGC21854 MPZL1 1q23.2 myelin protein zero-like 1 FLJ21047 1q23.3 hypothetical protein FLJ21047 SAC DKFZP564B167 1q24 DKFZP564B167 protein PC326 1q23.3 PC326 protein GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor) SELP 1q23.2-q41.2 selectin P (granule membrane protein 140kDa, antigen CD62) SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3795 - 209 - He (2006)
    - - 3898 29.1 269 - He (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunespleen    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • an extracellular single immunoglobulin like domain
  • two putatives sites of glycosylation
  • single transmembrane segment
  • two tyrosine phosphorylation sites
  • conjugated GlycoP , PhosphoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • myelin P0 protein family
  • CATEGORY receptor membrane tyrosine
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • play an important role in cell signaling
  • may be important in the predisposition to schizophrenia
  • with SIRPA have been implicated in extracellular matrix-dependent signaling
  • having a potential role in adhesion-dependent signaling because it becomes inducibly tyrosyl-phosphorylated upon plating cells onto fibronectin, yet it fails to do so in response to growth factors
  • might serve as an adhesion-regulated signaling molecule
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SHP-2, cSrc, concanavalin A (Con A)
  • cell & other
    REGULATION
    activated by phosphorylation cSrc
    inhibited by dephosphorylation SHP-2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in schizophrenia brain tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS