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FLASH GENE
Symbol MPST contributors: mct/npt - updated : 13-06-2008
HGNC name mercaptopyruvate sulfurtransferase
HGNC id 7223
Corresponding disease
MCDU mercaptolactate-cysteine disulfiduria
Location 22q13.1      Physical location : 37.415.701 - 37.425.862
Synonym name
  • rhodanese
  • human liver rhodanese
  • Synonym symbol(s) MST,TST2, MGC24539
    EC.number 2.8.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S277 - IL2RB - RAC2 - MPST - LGALS1 - PVALB - D22S283 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1450 - 297 - Billaut-Laden (2006)
    4 - 1626 - 297 - Billaut-Laden (2006)
    3 - 1352 - 297 - Billaut-Laden (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure alpha-beta structure
    HOMOLOGY
    Homologene
    FAMILY
  • rhodanese family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds
  • may be involved in cyanide degradation and in thiosulfate biosynthesis
  • playing a central role in both cysteine degradation and cyanide detoxification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCDU
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS