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FLASH GENE

Symbol

MPPE1

contributors: npt/shn - updated : 23-05-2010

HGNC name	metallophosphoesterase 1
HGNC id	15988

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18p11.21      Physical location : 11.883.473 - 11.908.641
Synonym name	metallophosphoesterase
	post-GPI-attachment to proteins 5
Synonym symbol(s)	PGAP5
EC.number	3.1.-.-

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation, tail to tail
text	in tail to tail orientation, partially overlapping with the 3' UTR of GNAL
STRUCTURE	25.17 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D18S1116 - D18S482 - MPPE1 - D18S71 - D18S453 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_023075 11 - 2806 NP_075563 - 396 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	predicted signal sequence of 45 AA at the N terminus
	240 AA metallophosphoesterase domain
	a phosphoesterase motif on the lumenal side
	an ER retrieval signal at the C terminus
	C terminal 24 AA transmembrane domain

conjugated

MetalloP

HOMOLOGY

interspecies	ortholog to MPPE1, Pan troglodytes
	ortholog to Mppe1, Rattus norvegicus
	ortholog to Mppe1, Mus musculus
	ortholog to mppe1, Danio rerio

Homologene

FAMILY

dimetal-containing phosphoesterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	hydrolase activity
	required for processing of the glycan moiety on glycosylphosphatidylinositol (GPI) (Fujita et al, 2009)
	role in transport of GPI-APs from the ER to the Golgi (Fujita et al, 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GPI-AP and p23 (Fujita et al, 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS