Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MPP7 contributors: mct - updated : 06-05-2009
HGNC name membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
HGNC id 26542
Location 10p12.1      Physical location : 28.339.922 - 28.571.067
Synonym symbol(s) FLJ32798, RP11-218D6.5
DNA
TYPE functioning gene
STRUCTURE 231.15 kb     19 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - D10S525 - D10S1771 - MPP7 - D10S588 - D10S174 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 5207 65.4 576 - 2007 17332497
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal L27 domain not sufficient for interaction with DLG1 but interacts efficiently only if MPP7 is in a complex with LIN7A or -C
  • a guanylate kinase-like domain
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to murine Mpp7
    homolog to zebrafish hmp
    Homologene
    FAMILY
  • MAGUK-p55 subfamily
  • p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • playing a role essential for recycling GMP and indirectly, cGMP
  • targeting to the lateral surface of epithelial cells via its L27N domain, through an interaction with DlG1
  • having a potential role in diabetes by perturbed islet cell polarity in insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex between DLG1 and MPP7 promotes epithelial cell polarity and tight junction formation
  • tripartite complex with DLG1 and LIN7A or LIN7C
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between endogenous DLG1 and MPP7
  • dimerizes with all three LIN7 family members (LIN7A, -B, and -C) through interaction of the single L27 domain of LIN7 with the carboxyl-terminal L27 domain of MPP7
  • dimer of MPP7 with LIN7A or LIN7C associates with DLG1 through an interaction requiring the amino-terminal L27 domain of MPP7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for OAS
    Marker
    Therapy target
    ANIMAL & CELL MODELS