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FLASH GENE
Symbol MPP6 contributors: mct - updated : 26-03-2012
HGNC name membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
HGNC id 18167
Location 7p15.3      Physical location : 24.613.084 - 24.727.497
Synonym name
  • VELI associated MAGUK 1
  • protein associated with Lin7 2
  • MAGUK protein p55T
  • Synonym symbol(s) PALS2, VAM1, p55T
    DNA
    TYPE functioning gene
    STRUCTURE 114.41 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MPP6 7p15 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) LOC392754 7 similar to importin alpha 1b NPY 7p15.1 neuropeptide Y LOC392983 7 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (PRO1608) DFNA5 7p15 deafness, autosomal dominant 5 ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa OSBPL3 7p15 oxysterol binding protein-like 3 ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 KIAA0632 7q22.1 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 MPP6 7p15 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 DFNA5 7p15 deafness, autosomal dominant 5 LOC392755 7 similar to ADP-ribosylation factor 6 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 CYCS 7p21.2 cytochrome c, somatic CYP3A7 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 7 C7orf31 7p15.2 chromosome 7 open reading frame 31 OSBPL3 7p15 oxysterol binding protein-like 3 CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 LOC392873 7 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2201 61 540 - 2002 11927608
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine   
     liver   highly
    Nervousbrain   highly
    Reproductivefemale systemovary   
     male systemmale genital tractseminiferous tubule   Homo sapiens
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    NervousSchawnn cell Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain
  • a central SH3 domain
  • a C terminal GUK domain
  • a EPB41 binding domain
  • a L27 domain targeting MPP to tight junction
  • a leucine zipper and two phosphorylation sites
  • HOMOLOGY
    interspecies homolog to murine Mpp6
    intraspecies homolog to MPP2
    Homologene
    FAMILY
  • MAGUK family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • in the seminiferous tubules, MPP6 was localized similarly to EPB41L2 along cell membranes of the spermatogonium and early spermatocytes (Pubmed 22025680)
  • basic FUNCTION
  • promoting the assembly of a VELII (LIN7A) containing protein complex in neuronal as well as epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with CRB1 and INADL
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to VEL1 (LIN7A)
  • MPP6 was interacting with EPB41L2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS