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FLASH GENE
Symbol MPP3 contributors: npt/ - updated : 10-05-2006
HGNC name membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
HGNC id 7221
Location 17q21.31      Physical location : 41.878.168 - 41.910.547
Synonym name
  • discs, large (Drosophila) homolog 3
  • palmitoylated membrane protein 3
  • protein MPP3
  • MAGUK p55 subfamily member 3
  • Synonym symbol(s) DLG3
    DNA
    TYPE functioning gene
    STRUCTURE 32.37 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) RPIP8 17p13.2 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2842 - 585 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland  
     male systemtestis   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Dlg,(DHR/GLGZ/PDZ) motif
  • a SH3 domain
  • HOMOLOGY
    interspecies homolog to Drosophila lethal discs large tumor suppressor protein (Dlg)
    Homologene
    FAMILY
  • MAGUK family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • localized at the photoreceptor synapse and at the subapical region adjacent to adherens junctions at the OLM (outer limiting membrane)
  • colocalized with MPP5 and CRB1 at the subapical region
  • basic FUNCTION
  • involved in coupling the cytoskeleton to the cell membrane
  • playing a role in photoreceptor polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • forms a tripartite protein complex with EPB41L3 and CADM1, MPP2, MPP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CADM1 (involved in the same cascade of cell-cell interaction, and disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer)
  • with MPP2 and MPP1, interact with CADM1 and EPB41L3 mainly through PDZ-binding motif of CADM1 and the core region of FERM domain in EPB41L3, respectively (Sakurai-Yageta (2009)
  • cell & other
    REGULATION
    Other palmitoylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS