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FLASH GENE
Symbol MPP3 contributors: npt/ - updated : 10-05-2006
HGNC name membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
HGNC id 7221
Location 17q21.31      Physical location : 41.878.168 - 41.910.547
Synonym name
  • discs, large (Drosophila) homolog 3
  • palmitoylated membrane protein 3
  • protein MPP3
  • MAGUK p55 subfamily member 3
  • Synonym symbol(s) DLG3
    DNA
    TYPE functioning gene
    STRUCTURE 32.37 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2842 - 585 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland  
     male systemtestis   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Dlg,(DHR/GLGZ/PDZ) motif
  • a SH3 domain
  • HOMOLOGY
    interspecies homolog to Drosophila lethal discs large tumor suppressor protein (Dlg)
    Homologene
    FAMILY
  • MAGUK family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • localized at the photoreceptor synapse and at the subapical region adjacent to adherens junctions at the OLM (outer limiting membrane)
  • colocalized with MPP5 and CRB1 at the subapical region
  • basic FUNCTION
  • involved in coupling the cytoskeleton to the cell membrane
  • playing a role in photoreceptor polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • forms a tripartite protein complex with EPB41L3 and CADM1, MPP2, MPP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CADM1 (involved in the same cascade of cell-cell interaction, and disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer)
  • with MPP2 and MPP1, interact with CADM1 and EPB41L3 mainly through PDZ-binding motif of CADM1 and the core region of FERM domain in EPB41L3, respectively (Sakurai-Yageta (2009)
  • cell & other
    REGULATION
    Other palmitoylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS