Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MPP2 contributors: npt/ - updated : 01-03-2006
HGNC name membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
HGNC id 7220
Location 17q21.31      Physical location : 41.952.726 - 41.985.113
Synonym name
  • discs large, homolog 2
  • palmitoylated membrane protein 2
  • MAGUK p55 subfamily member 2
  • protein MPP2
  • Synonym symbol(s) DLG2, DKFZp761D0712, DKFZp686J2189, DKFZp686A06252
    DNA
    TYPE functioning gene
    STRUCTURE 32.39 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4412 - 552 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Dlg (DHR/GLGZ/PDZ) motifs
  • a SH3 domain
  • a C terminal GUK domain
  • HOMOLOGY
    interspecies homolog to Drosophila lethal discs large tumor suppressor protein (Dlg)
    Homologene
    FAMILY
  • MAGUK family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in coupling the cytoskeleton to the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • forms a tripartite protein complex with EPB41L3 and CADM1, MPP1, MPP3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with MPP1 and MPP3, interact with CADM1 and EPB41L3 mainly through PDZ-binding motif of CADM1 and the core region of FERM domain in EPB41L3, respectively (Sakurai-Yageta (2009)
  • cell & other
    REGULATION
    Other palmitoylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS