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FLASH GENE
Symbol MPHOSPH8 contributors: mct - updated : 28-01-2011
HGNC name M-phase phosphoprotein 8
HGNC id 29810
Location 13q12.11      Physical location : 20.207.787 - 20.247.598
Synonym name
  • two hybrid associated protein No. 3 with RanBPM
  • M-phase phosphoprotein, mpp8
    • Synonym symbol(s) RP11-523H24.1, FLJ35237, HSMPP8, TWA3, mpp8
    EC.number 2.4.2.30
    DNA
    TYPE functioning gene
    STRUCTURE 39.81 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4281 97.2 860 - 1996 8885239
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a chromodomain that is a methyl-H3K9-binding motif near the N-terminal
  • four copies of ankyrin-repeats near the C-terminal
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • encoded genuine M phase phosphoproteins
  • methyl-H3K9-binding protein which contributes to tumour progression
  • recognizes methyl-H3K9 marks and directs DNA methylation to repress tumour suppressor gene expression and, in turn, has an important function in epithelial-to-mesenchymal transition and metastasis
  • couples histone H3K9 methylation and DNA methylation for tumour suppressor gene silencing and metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targets the E-cadherin (CDH1) gene promoter and modulates the expression of this key regulator of cell behaviour and tumour progression through its methyl-H3K9 binding
  • could repress E-cadherin expression through methyl-H3K9 binding
  • interacts with H3K9 methyltransferases EHMT1 and SETDB2 , as well as DNA methyltransferase 3A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS