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FLASH GENE
Symbol MPC2 contributors: mct - updated : 10-04-2013
HGNC name mitochondrial pyruvate carrier 2
HGNC id 24515
Location 1q24.2      Physical location : -
Synonym name
  • brain protein 44
  • Synonym symbol(s) MGC125752, MGC125753, DKFZp564B167, BRP44
    DNA
    TYPE functioning gene
    STRUCTURE 20.39 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2220 14.15 127 - 2012 22628554
    6 - 2154 14.15 127 - 2012 22628554
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast Fmp43 protein
    homolog to murine Brp44
    Homologene
    FAMILY PF0041 (0-44) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
  • basic FUNCTION
  • essential for mitochondrial pyruvate transport (
  • MPC1 and MPC2 form an essential part of the mitochondrial pyruvate carrier
  • MPC1 and MPC2 are obligatory components of facilitated pyruvate transport in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
  • Variant & Polymorphism SNP
  • SNP rs10489202 located in intron 1 of BRP44, is associated to schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS