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FLASH GENE
Symbol MOXD1 contributors: mlc/np - updated : 10-11-2007
HGNC name monooxygenase, DBH-like 1
HGNC id 21063
Location 6q23.1-q23.3      Physical location : 132.617.194 - 132.722.664
Synonym name
  • monooxygenase X
  • dopamine-oxygenase
  • DBH-like monooxygenase protein 1
    • Synonym symbol(s) MOX, PRO5780, UNQ2493, dJ248E1.1
    EC.number 1.14.17.-
    DNA
    TYPE functioning gene
    STRUCTURE 104.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S304 - D6S1639 - D6S407 - D6S472 - (D6S413 - D6S975 ) - MOXD1 - D6S1036 - D6S976 - D6S314 - D6S1569 - D6S311 - qter
    Authors Chambers (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3039 69.6 613 - Xin (2004)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Hearing/Equilibriumear   highly
    Reproductivemale systemprostate  highly
    Respiratorylung    
    Skin/Tegumentskin   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage   
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • several cysteine residues likely to be involved in disulfide bond formation
    • mono polymer homomer , tetramer
    HOMOLOGY
    intraspecies homolog to dopamine beta hydroxylase (DBH)
    Homologene
    FAMILY
  • copper type 2, ascorbate-dependent monooxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in conversion of dopamine to noradrenaline
  • predicted to hydroxylate a hydrophobic substrate in the endoplasmic reticulum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • copper and ascorbate
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS