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FLASH GENE
Symbol MOV10L1 contributors: mct - updated : 11-09-2010
HGNC name Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
HGNC id 7201
Location 22q13.33      Physical location : 50.528.434 - 50.600.115
Synonym name
  • novel protein similar to mouse Mov10
  • cardiac-specific isoform of Mov10l1
  • Mov10 (mouse)-like 1
  • putative helicase Mov10l1
  • Synonym symbol(s) FLJ33421, Csm, DJ402G11.8, DKFZp434B0717, FLJ33421
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 71.62 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BRD1 22q13.33 bromodomain containing 1 ZBED4 22q13.33 zinc finger, BED domain containing 4 ALG12 22q13.3 zinc finger, BED domain containing 4 MGC11256 22p13 hypothetical protein MGC11256 LOC164714 22q13.33 similar to RIKEN cDNA 1700019P01 MLC1 22q13.33 megalencephalic leukoencephalopathy with subcortical cysts 1 MOV10L1 22q13.33 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) PANX2 22q13.33 pannexin 2 PP2447 22q13.33 hypothetical protein PP2447 SELO 22q13.33 selenoprotein O TUBGCP6 22q13.31-q13.33 tubulin, gamma complex associated protein 6 HDAC10 22q13.31 histone deacetylase 10 MAPK12 22q13.33 mitogen-activated protein kinase 12 MAPK11 22q13.33 mitogen-activated protein kinase 11 PLXNB2 22q13.31-q13.33 plexin B2 KIAA0685 22q13.3 plexin B2 SBF1 22q13.33 SET binding factor 1 FLJ21135 ALDRL6 22q13.3 aldehyde reductase (aldose reductase) like 6 BC002942 22q13.33 hypothetical protein BC002942 384D8-2 22q13.33 hypothetical protein 384D8_6 SCO2 22q13.33 SCO cytochrome oxidase deficient homolog 2 (yeast) ECGF1 22q13.3 endothelial cell growth factor 1 (platelet-derived)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3828 129.81 1165 - Wang (2001)
    - - 3951 130.1 1165 - Wang (2001)
    - - 1351 37.4 338 - Wang (2001)
    27 - 3966 135.2 1211 - Wang (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node    
    Reproductivemale systemtestis  specific
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Mus musculus
    Reproductivespermatocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Mov10
    Homologene
    FAMILY
  • DNA2/NAM7 helicase family
  • SDE3 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text found in small quantities in the nucleus
    basic FUNCTION
  • required for rapid turnover of mRNAs containing a premature translational termination codon
  • may play a role in male germ cell development
  • putative germline-specific RNA helicase (Lovasco 2010)
  • may be functioning as a key component of a safeguard mechanism for the genetic information in male germ cells of mammals (Frost 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MOV10L1 expression is sensitive to TAF4B level, linking TAF4B to the posttranscriptional control of ovarian gene expression
  • interacts with the Piwi proteins PIWIL1 and PIWIL2 and also with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes, and essential for male fertility (Frost 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mov10l1-null (Mov10l1&
  • 8722;/&
    8722;) mice were infertile due to apoptotic loss of early pachytene spermatocytes (Frost 2010)