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FLASH GENE
Symbol MOV10L1 contributors: mct - updated : 05-07-2022
HGNC name Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
HGNC id 7201
Corresponding disease
SPGF73 spermatogenic failure 73
Location 22q13.33      Physical location : 50.528.434 - 50.600.115
Synonym name
  • novel protein similar to mouse Mov10
  • cardiac-specific isoform of Mov10l1
  • Mov10 (mouse)-like 1
  • putative helicase Mov10l1
  • Synonym symbol(s) FLJ33421, Csm, DJ402G11.8, DKFZp434B0717, FLJ33421, CHAMP, SPGF73
    EC.number 3.6.1.-/ 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 71.62 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3819 129.81 1165 - 2002 11839499
    26 - 4192 130.1 1165 - 2002 11839499
    9 - 1351 37.4 338 - 2002 11839499
    27 - 3966 135.2 1211 - 2002 11839499
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node    
    Reproductivemale systemtestis    Homo sapiens
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Mus musculus
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Mov10
    Homologene
    FAMILY
  • DNA2/NAM7 helicase family
  • SDE3 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text found in small quantities in the nucleus
    basic FUNCTION
  • required for rapid turnover of mRNAs containing a premature translational termination codon
  • may play a role in male germ cell development
  • putative germline-specific RNA helicase (Lovasco 2010)
  • may be functioning as a key component of a safeguard mechanism for the genetic information in male germ cells of mammals
  • MOV10L1 acts upstream of Piwi proteins in the primary processing of pachytene piRNAs, suggesting that, distinct from pre-pachytene piRNAs, pachytene piRNAs fulfill a unique function in maintaining post-meiotic genome integrity
  • testis-specific MOV10L1 is essential for spermatogenesis and PIWI-interacting RNAs biogenesis, whereas MOV10 is ubiquitous and multifunctional
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MOV10L1 expression is sensitive to TAF4B level, linking TAF4B to the posttranscriptional control of ovarian gene expression
  • interacts with the Piwi proteins MILI and MIWI and also interacts with HSPA2, a testis-enriched chaperone expressed in pachytene spermatocytes and also essential for male fertility
  • MOV10L1 selectively binds piRNA precursor transcripts and is essential for the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins
  • RG4 (RNA G-Quadruplex) unwinding by MOV10L1 facilitates the cleavage of this specific RNA structure by an endonuclease
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF73
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Primary spermatocytes of Mov10l1(-/-) mice show activation of LTR and LINE-1 retrotransposons, followed by cell death, causing male infertility and a complete block of spermatogenesis at early prophase of meiosis I
  • Mov10l1 mutant mice exhibit meiotic arrest and male sterility