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FLASH GENE
Symbol MOV10 contributors: mct/shn - updated : 29-09-2015
HGNC name Mov10, Moloney leukemia virus 10, homolog (mouse)
HGNC id 7200
Location 1p13.2      Physical location : 113.217.047 - 113.243.367
Synonym name
  • functional spliceosome-associated protein 113
  • Moloney leukemia virus 10 protein
  • Mov10 (Moloney leukemia virus 10, mouse) homolog
  • putative helicase MOV-10
  • Synonym symbol(s) KIAA1631, gb110, FLJ32791, MGC2948, fSAP113, DKFZp667O1423, RP11-426L16.2
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 26.43 kb     21 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   enhancer
    text structure four GC and GT-box motives, the fourth interacts with FTZF1/ELP
    MAPPING cloned Y linked N status provisional
    Map pter - D1S2746 - D1S487 - MOV10 - D1S2756 - D1S2881 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3653 115 1003 - 2009 19665004
    21 - 3538 115 1003 - 2009 19665004
    22 - 4515 - 947 - 2009 19665004
    EXPRESSION
    Rna function highly in testis and ovary
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines undifferentiated F9 ambryonal carcinoma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region may be responsible for the formation of MOV10–TERT complex (Nakano 2009)
  • NP (ATP) binding domain
  • DEAG Box
  • HOMOLOGY
    interspecies ortholog to Mov10, Mus musculus
    ortholog to Mov10, Rattus norvegicus
    homolog to drosophila Armitage
    ortholog to MOV10, Pan troglodytes
    Homologene
    FAMILY
  • RNA helicase superfamily-2
  • argonaute-associated proteins family
  • SDE3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,chromatin/chromosome
    text
  • both APOBEC3G and MOV10 have been found to co-localize with AGO1 and AGO2 in P-bodies and stress granules
  • MOV10 and APOBEC3G (A3G) localize to cytoplasmic granules called processing bodies (P bodies)
  • basic FUNCTION
  • may be an helicase with an important function in development and in control of cell proliferation
  • required to mediate microRNA-guided mRNA cleavage
  • may play a role in RNA-directed transcription
  • involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA
  • may have some role(s) in normal cells and it may regulate telomerase activity to bind to TERT and telomere DNA
  • preferentially expressed in telomerase-positive organs and the cancer cells, and physically and functionally associated with TERT and telomere
  • has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection
  • involved in transcriptional silencing by PcG complexes
  • can potently inhibit HIV-1 replication at multiple stages
  • may be potentially a component of a cellular pathway or process that selectively regulates the replication of endogenous retroelements in somatic cells
  • putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibiting retrovirus replication
  • may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements
  • MOV10 contributes to the cellular control of LINE-1 replication
  • MOV10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide
    PHYSIOLOGICAL PROCESS development
    text a putative RNA helicase
    PATHWAY
    metabolism
    signaling
    a component
  • Polycomb-repressive complex 1, PRC1
  • INTERACTION
    DNA chromatin in an RNA-dependent manner
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • Polycomb-repressive complex 1, PRC1
  • APOBEC3G binds to a domain at the C terminus in MOV10, where it competitively inhibits the binding of AGO2 to that same domain
  • MOV10 functions in UPF1-mediated mRNA degradation as an RNA clearance factor to resolve structures and displace proteins from 3prime UTRs
  • FMR1 associates with the RNA helicase MOV10, also associated with the microRNA pathway, in an RNA-dependent manner and facilitates MOV10 association with RNAs in brain and cells, suggesting a cooperative interaction
  • RNA helicase MOV10 plays a role in WNT5A synthesis and secretion
  • HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev
  • cell & other
    REGULATION
    repressed by acyclic AMP,retinsic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS