basic FUNCTION
| may be an helicase with an important function in development and in control of cell proliferation |
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required to mediate microRNA-guided mRNA cleavage |
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may play a role in RNA-directed transcription |
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involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA |
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may have some role(s) in normal cells and it may regulate telomerase activity to bind to TERT and telomere DNA |
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preferentially expressed in telomerase-positive organs and the cancer cells, and physically and functionally associated with TERT and telomere |
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has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection |
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involved in transcriptional silencing by PcG complexes |
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can potently inhibit HIV-1 replication at multiple stages |
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may be potentially a component of a cellular pathway or process that selectively regulates the replication of endogenous retroelements in somatic cells |
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putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibiting retrovirus replication |
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may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements |
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MOV10 contributes to the cellular control of LINE-1 replication |
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MOV10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity |
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MOV10 acts as an anti-influenza virus factor through specifically inhibiting the nuclear transportation of nucleoprotein (NP) and subsequently inhibiting the function of the viral ribonucleoprotein (vRNP) complex |
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is essential for normal neuronal development and brain function and preferentially binds RNAs involved in actin binding, neuronal projection, and cytoskeleton |
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is essential for gastrulation and normal CNS development |
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testis-specific MOV10L1 is essential for spermatogenesis and PIWI-interacting RNAs biogenesis, whereas MOV10 is ubiquitous and multifunctional |
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FMR1 and MOV10 have an important regulatory role in GRIN1 mediated translation at the synapse |
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potential role for MOV10 in modulating Coronaviruses (CoVs) pathogenesis |
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DDX21 and MOV10 RNA helicases limit viral infection and replication of SARS-CoV-2, but in contrast, DDX1, DDX5, and DDX6 are required for SARS-CoV-2 infection |