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FLASH GENE
Symbol MOS contributors: mlc - updated : 15-11-2007
HGNC name v-mos Moloney murine sarcoma viral oncogene homolog
HGNC id 7199
Location 8q11      Physical location : 57.025.501 - 57.026.541
Synonym name Oncogene MOS, Moloney murine sarcoma virus
Synonym symbol(s) MSV, CSFM1, MGC119962, MGC119963
EC.number 2.7.1.37
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11 LOC157708 8q11.23 similar to SPC18 protein RP1 8q11.21-q11.23 retinitis pigmentosa 1 (autosomal dominant) LOC392223 8 similar to ribosomal protein L7-like 1 LOC389660 8 similar to polycystin 1-like 3 LOC392224 8 similar to hypothetical protein 4932417K07 KIAA1889 8q11.23 KIAA1889 protein FLJ32370 8q11.23 hypothetical protein FLJ32370 NCOA6IP 8p11 nuclear receptor coactivator 6 interacting protein LYN 8q13 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog PSMC6P 8q11.23 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene RPS20 8 ribosomal protein S20 MOS 8q11 v-mos Moloney murine sarcoma viral oncogene homolog PLAG1 8q12 pleiomorphic adenoma gene 1 MGC2217 RDH-E2 8q12.1 retinal short chain dehydrogenase reductase PENK 8q11.23-q12 proenkephalin LOC389662 8 similar to septin 10 isoform 1 LOC346950 8q11.23 similar to ribosomal protein L37 FLJ20421 8q11.23 hypothetical protein FLJ20421 DKFZP434F122 8q12.1 DKFZP434F122 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1041 - 346 - Kalejs (2006)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Moloney sarcoma viral (v-mos) oncogene
Homologene
FAMILY Ser/Thr protein kinase family
CATEGORY enzyme , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division
  • principal meiotic regulator, blocking cells at metaphase II
  • enhancing dephosphorylation of multiple Cdc2 Sites that control FBXO43 stability
    • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    text control of meioses
    PATHWAY
    metabolism
    signaling
    a component
  • component of a large multiprotein complex known as the cytostatic factor (CSF)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein interacting with REC8 (coordinated expression of MOS and REC8 regulate the extent of arrested mitoses and polyploidy)
    cell & other
  • stabilizing the M-phase promoting factor (MPF)
  • activating mitogen-activated protein (MAP) kinase pathway
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    aberrantly activated during mitotic catastrophe in TP53 mutated lymphoma cells after irradiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS