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Symbol MORF4L1 contributors: mct/npt/pgu - updated : 31-01-2017
HGNC name mortality factor 4 like 1
HGNC id 16989
Location 15q25.1      Physical location : 79.165.171 - 79.190.072
Synonym name
  • MORF-related gene on chromosome 15
  • transcription factor-like protein MRG15
  • MSL3-1 protein
  • Synonym symbol(s) MRG15, Eaf3, FWP006, HsT17725, MGC10631, MORFRG15, S863-6
    TYPE functioning gene
    STRUCTURE 24.96 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC146013 15q24.1 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) KIP2 15q24.3 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) IDH3A 15q25.1-q25.2 isocitrate dehydrogenase 3 (NAD+) alpha BG1 15q24-q25 isocitrate dehydrogenase 3 (NAD+) alpha DNAJA4 15q24.1 DnaJ (Hsp40) homolog, subfamily A, member 4 REC14 15q24.1 recombination protein REC14 CRABP1 15q24 cellular retinoic acid binding protein 1 IREB2 15q24 iron-responsive element binding protein 2 LOC123688 15q24.1 similar to RIKEN cDNA C630028N24 gene PSMA4 15q24.1 proteasome (prosome, macropain) subunit, alpha type, 4 CHRNA5 15q24 cholinergic receptor, nicotinic, alpha polypeptide 5 CHRNA3 15q24 cholinergic receptor, nicotinic, alpha polypeptide 3 CHRNB4 15q24 cholinergic receptor, nicotinic, beta polypeptide 4 LOC390612 15 similar to ribosomal protein L18; 60S ribosomal protein L18 LOC388142 15 LOC388142 LOC390613 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) ADAMTS7 15pter-qter a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 LOC390614 15 similar to cDNA sequence BC053073; G-protein coupled receptor SALPR; somatostatin and angiotensin-like peptide receptor LOC388143 15 similar to 60S ribosomal protein L21 MORF4L1 15q24 mortality factor 4 like 1 CTSH 15q24-q25 cathepsin H RASGRF1 15q24 Ras protein-specific guanine nucleotide-releasing factor 1 LOC390615 15 similar to HNRPC protein LOC390616 15 similar to RIKEN cDNA 6430502M16 gene P24B 15q24-q25 integral type I protein KIAA1024 15q24.2 KIAA1024 protein
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1894 37.1 323 - 2012 22728643
    13 - 2011 41.3 362 - 2012 22728643
    10 - 1799 - 235 - 2012 22728643
    12 - 1847 - 235 - 2012 22728643
    - - 1747 - 235 - 2012 22728643
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnervecranial nerve  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    at STAGE
    physiological period embryo, fetal
    Text pharyngeal arch, fetal cochlea
  • putative chromo domain in the N-terminal part that has been shown to participate in chromatin remodeling and transcription regulation (may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains)
  • chromatin organization modifier domain
  • MRG domain responsible for transcriptional regulation via chromatin remodeling by histone acetylation
  • C-terminal part forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein MRFAP1 during transcriptional regulation
    interspecies homolog to yeast Eaf3
  • mortality family of transcription factors
  • chromodomain superfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • playing a role in transcriptional regulation via chromatin remodeling by histone acetylation
  • having an essential role in embryonic development via chromatin remodeling and transcriptional regulation
  • transcription factor that plays a vital role in embryonic development, cell proliferation and cellular senescence
  • conserved chromodomain protein that associates with histone deacetylases (HDACs) and Tip60-containing histone acetyltransferase (HAT) complexes
  • plays a role in both transcriptional silencing and activation
  • mediates DNA-damage-response functions of the BRCA complex in chromatin
  • member of the BRCA multiprotein complex, essential for the maintenance of the genome integrity and DNA repair
  • is acting in a histone acetylation complex involving KAT5 to modify chromatin via acetylation of histone H4 at the CDC2 promoter to activate transcription
  • contributes likely to the regulation of cell genesis in the retina
  • maintenance of interphase chromosome compaction and homolog pairing status requires both MORF4L1 and TMPRSS4
  • chromodomain-containing chromatin-binding protein, recruiting diverse chromatin-associated complexes that regulate gene transcription, DNA repair, and RNA splicing
  • multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells
  • is essential for pre-mRNA splicing during spermatogenesis and epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorders underlying male infertile patients
    a component
  • part of an MORF4L1/PHF12/SIN3A complex may be implicated in the unique functions of MORF4L1
  • complex containing the corepressor SIN3B, HDAC1, MORF4L1 and PHF12 plays important roles in regulation of transcription
    small molecule
  • associates with at least two nucleoprotein complexes that include histone acetyltransferases and/or histone deacetylases
  • MORF4L1 and MORF4L2 proteins are MRGBP-associating proteins
  • interacting with RBP2 (associated with MORF4L1 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state)
  • PALB2-associated protein that ensures regulated recombination events (abrogation of the PALB2-MORF4L1 interaction resulted in elevated sister chromatid exchange frequencies)
  • PALB2 binds directly to a conserved chromodomain protein, MORF4L1, which is a component of histone acetyltransferase-deacetylase complexes
  • MRFAP1 may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation
  • PHF12 associates with a chromatin interacting protein complex comprised of MORF4L1, SIN3B, and HDAC1, that functions as a transcriptional modulator
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    MORF4L1 deficient neural stem/progenitor cell (NSC) exhibit severe defects in DNA damage response following ionizing radiation
    Variant & Polymorphism
    Candidate gene
    Therapy target