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FLASH GENE
Symbol MORF4 contributors: npt - updated : 18-03-2002
HGNC name mortality factor 4
HGNC id 15773
Location 4q33-q34.1      Physical location : 174.537.087 - 174.537.794
Synonym name
  • senescence (cellular)-related 1
  • cell senescence related gene 3, (reversal of the immortal phenotype in cell line, complementation group B)
  • transcription factor-like protein MORF4
  • Synonym symbol(s) SEN, SEN1, CSRG3, CSRB, CSR
    DNA
    TYPE functioning gene
    STRUCTURE 0.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC132604 4q34.1 GalNAc transferase 10 isoform-like GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) HMGB2 4q31 high-mobility group box 2 SAP30 4q34.1 sin3-associated polypeptide, 30kDa SCRG1 4q31-q32 sin3-associated polypeptide, 30kDa LOC391716 4 similar to 60S ribosomal protein L5 LOC389242 4 LOC389242 HAND2 4q33 heart and neural crest derivatives expressed 2 FLJ11539 4q34.1 hypothetical protein FLJ11539 MORF4 4q33-q34.1 mortality factor 4 LOC391717 4 similar to RAN protein LOC389243 4 LOC389243 FBXO8 4q34.1 F-box only protein 8 KIAA1712 4q34 KIAA1712 HPGD 4q34-q35 hydroxyprostaglandin dehydrogenase 15-(NAD) GLRA3 4q33-q34 glycine receptor, alpha 3 ADAM29 4q34 a disintegrin and metalloproteinase domain 29 LOC391718 4 similar to hypothetical protein MGC2776 GPM6A 4q34 glycoprotein M6A WDR17 4q34 WD repeat domain 17 TSARG2 4q34.2 testis and spermatogenesis cell related protein 2 ASB5 4q34.1 ankyrin repeat and SOCS box-containing 5 FLJ22649 4q34.2 hypothetical protein FLJ22649 similar to signal peptidase SPC22/23 VEGFC 4q34 vascular endothelial growth factor C
    regionally located in the TSG4C region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 708 26 235 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transcription factor-like motifs
  • HOMOLOGY
    interspecies homolog to murine Tex189
    homolog to murine Mrgx
    homolog to C.elegans y40b1a.3
    intraspecies homolog to MRG15
    Homologene
    FAMILY
  • MRG family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • not essential for human keratinocyte immortality
  • inducing a senescent-like phenotype in immportal cell lines
  • playing a role in growth regulation and replicative senescence
  • capable of reversing the immortal phenotype of a subset of immortal cells
  • acting as a transcription factor or interact with other proteins to inhibit or entrance their function
  • CELLULAR PROCESS cell life, senescence
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text aging
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS