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FLASH GENE
Symbol MON2 contributors: mct - updated : 23-02-2015
HGNC name MON2 homolog (yeast)
HGNC id 29177
Location 12q14.1      Physical location : 62.860.596 - 62.991.362
Synonym name KIAA1040 protein
Synonym symbol(s) KIAA1040, MGC35493
DNA
TYPE functioning gene
STRUCTURE 130.77 kb     35 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
36 - 10457 - 1645 - 2011 21450827
36 - 10440 - 1675 - 2011 21450827
35 - 10379 - 1717 - 2011 21450827
42 - 10351 - 1711 - 2011 21450827
34 - 10292 - 1688 - 2011 21450827
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Lymphoid/Immunelymph node   predominantly
 spleen   moderately
Reproductivemale systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to yeast Ysl2p
Homologene
FAMILY
CATEGORY enzyme , storage
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,Golgi
text
  • localized to trans-Golgi network which was dependent on both its N and C termini
  • basic FUNCTION
  • may have hydrogen-transporting ATPase activity
  • is a scaffold protein with novel conserved domains, and is involved in multiple aspects of endomembrane trafficking
  • is distantly related to the guanine nucleotide exchange factors (GEFs) that activate ARF1 on Golgi membranes
  • cellular factors VPS18 and MON2 are required for efficient production of infectious HIV-1 particles
  • involved in endosome-to-Golgi trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ATP synthesis coupled proton transport
    PATHWAY
    metabolism
    signaling
    a component
  • MON2 forms a complex with DOPEY1
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • DOPEY1 plays a widespread role in membrane organization, and MON2 acts as a scaffold to recruit the Golgi-localized pool of DOPEY1
  • directly interacts with GGA1, GGA2, GGA3 through the VHS domain
  • MON2 is a negative regulator of the monomeric G protein, ARL1
  • could be neither necessary nor sufficient for the guanine nucleotide exchange of ARL1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS