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FLASH GENE
Symbol MON1A contributors: mct/pgu - updated : 10-03-2015
HGNC name MON1 homolog A (yeast)
HGNC id 28207
Location 3p21.31      Physical location : 49.946.302 - 49.967.445
Synonym name vacuolar fusion protein MON1 homolog A
Synonym symbol(s) MGC13272, SAND1, FLJ97088
DNA
TYPE functioning gene
STRUCTURE 21.14 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2244 - 652 - 2007 17632513
5 - 1758 - 490 - 2007 17632513
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to MON1B
Homologene
FAMILY
  • SAND protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text is a cytosolic protein that peripherally associates with the ER
    basic FUNCTION
  • involved in trafficking of ferroportin and play an important role for trafficking of cell-surface and secreted molecules
  • protein that acts as a novel regulator of spleen iron release
  • is necessary for vesicular trafficking of proteins, including the iron-export protein ferroportin, to the macrophage cell membrane
  • required for phagosome maturation
  • plays a role in the movement of molecules through the secretory apparatus
  • MON1A and CCZ1 are critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses
  • role for MON1A in anterograde trafficking through the secretory apparatus
  • functions in efficient movement of molecules from the ER to the Golgi and from the Golgi to the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MON1A-CCZ1 complex triggers endosomal maturation by activating RAB7A7 on late endosomes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with cytoplasmic dynein to efficiently traffic vesicles from ER to Golgi
  • cell & other
    REGULATION
    induced by in human fibroblasts induced by herpes simplex virus 1 binding
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS