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FLASH GENE
Symbol MOGAT3 contributors: mct - updated : 13-01-2017
HGNC name monoacylglycerol O-acyltransferase 3
HGNC id 23249
Location 7q22.1      Physical location : 100.839.014 - 100.844.302
Synonym name acyl coenzyme A:monoacylglycerol acyltransferase 3
Synonym symbol(s) DC7, DGAT2L7, MGAT3, MGC119203, MGC119204
EC.number 2.3.1.20
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     7 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestineileum highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to highly to DGAT2
Homologene
FAMILY diacylglycerol acyltransferase family, MGAT family of enzymes
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • catalyze the synthesis of diacylglycerol (DAG) from monoacylglycerol (MAG), a committed step in dietary fat absorption (Cao 2007)
  • able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates
  • may also possess significant DGAT activity (Cao 2007)
  • functions as a novel triacylglycerol (TAG) synthase that catalyzes efficiently the two consecutive acylation steps in TAG synthesis (Cao 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    Triacylglycerol (TAG) synthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS