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FLASH GENE

Symbol

MOG

contributors: npt/ - updated : 15-01-2007

HGNC name	myelin oligodendrocyte glycoprotein
HGNC id	7197

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p22-p21.3      Physical location : 927.717 - 29.640.147
Synonym name	MOG Ig-AluB
	MOG alpha-6
Synonym symbol(s)	DAQB-92E24.2, MGC26137, MOGIG-2

DNA

TYPE	functioning gene
STRUCTURE	15.34 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001008228 - - 2050 NP_001008229 - 224 - Delarasse also called alpha3 NM_206812 - - 2002 NP_996535 - 208 - Delarasse also called alpha2 NM_206811 - - 1800 NP_996534 - 229 - Delarasse also called beta3 NM_206813 - - 2007 NP_996536 - 171 - Delarasse also called beta4 NM_001008229 - - 1731 NP_001008230 - 206 - Delarasse also called beta2 NM_002433 - - 1869 NP_002424 - 252 - Delarasse also called beta1 NM_206809 - - 2119 NP_996532 - 247 - Delarasse also called alpha1 NM_206810 - - 1752 NP_996533 - 213 - Delarasse also called beta5 NM_206814 - - 2257 NP_996537 - 171 - Delarasse also called alpha4

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala       brain diencephalon hypothalamus       nerve cranial nerve       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central white matter     Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig-like domain
	two transmembrane segments (2TM)

conjugated

GlycoP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

Homologene

FAMILY	immunologlobulin superfamily
	BNT/MOG subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

target of HOXD1 (TTTAATTGTA sequence is involved in HOXD1 binding to the MOG promoter but neighboring TAAT sites may also be needed) (Booth 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

susceptibility to multiple sclerosis to obsessive compulsive disorder

Variant & Polymorphism other	polymorphism associated to to obsessive compulsive disorder
	IgG but not IgM antibody titers to native MOG were significantly higher in MS patients compared with different control groups with the highest prevalence in primary progressive MS patients

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS