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FLASH GENE
Symbol MOG contributors: npt/ - updated : 15-01-2007
HGNC name myelin oligodendrocyte glycoprotein
HGNC id 7197
Location 6p22-p21.3      Physical location : 927.717 - 29.640.147
Synonym name
  • MOG Ig-AluB
  • MOG alpha-6
  • Synonym symbol(s) DAQB-92E24.2, MGC26137, MOGIG-2
    DNA
    TYPE functioning gene
    STRUCTURE 15.34 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    MAS1L 6p21 MAS1 oncogene-like LOC154545 6p21.33-p21.32 similar to ribosomal protein S17 GPR53P 6p21 G protein-coupled receptor 53, pseudogene LOC346170 6p21.32 similar to Olfactory receptor 2I2 UBD 6p21.3 ubiquitin D OR2H5P 6p21.31-22.2 olfactory receptor, family 2, subfamily H, member 5 pseudogene OR2H3 6p21.3 olfactory receptor, family 2, subfamily H, member 3 GABBR1 6p21.3 gamma-aminobutyric acid (GABA) B receptor, 1 SMT3H2P 6p21 SMT3 suppressor of mif two 3 homolog 2 (yeast) pseudogene MOG 6p22-p21.3 myelin oligodendrocyte glycoprotein LOC346171 6p21.32 similar to bA145L22.2 (novel KRAB box containing C2H2 type zinc finger protein) HCG4P11 6p21.3 HLA complex group 4 pseudogene 11 HLA-F 6p21.3 major histocompatibility complex, class I, F RPL23AP1 6p21.3 ribosomal protein L23a pseudogene 1 HCG9P5 6p21.3 HLA complex group 9 pseudogene 5 IFITM4P 6p21.32 interferon induced transmembrane protein 4 pseudogene 3.8-1.5 6p21.3 3.8-1.5 pseudogene HCP5P14 6p21.3 HLA complex P5 pseudogene 14
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2050 - 224 - Delarasse
    also called alpha3
    - - 2002 - 208 - Delarasse
    also called alpha2
    - - 1800 - 229 - Delarasse
    also called beta3
    - - 2007 - 171 - Delarasse
    also called beta4
    - - 1731 - 206 - Delarasse
    also called beta2
    - - 1869 - 252 - Delarasse
    also called beta1
    - - 2119 - 247 - Delarasse
    also called alpha1
    - - 1752 - 213 - Delarasse
    also called beta5
    - - 2257 - 171 - Delarasse
    also called alpha4
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala  
     braindiencephalonhypothalamus  
     nervecranial nerve   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Ig-like domain
  • two transmembrane segments (2TM)
  • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunologlobulin superfamily
  • BNT/MOG subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of HOXD1 (TTTAATTGTA sequence is involved in HOXD1 binding to the MOG promoter but neighboring TAAT sites may also be needed) (Booth 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • susceptibility to multiple sclerosis
  • to obsessive compulsive disorder
  • Variant & Polymorphism other
  • polymorphism associated to to obsessive compulsive disorder
  • IgG but not IgM antibody titers to native MOG were significantly higher in MS patients compared with different control groups with the highest prevalence in primary progressive MS patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS