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FLASH GENE
Symbol MNT contributors: mct/npt - updated : 09-09-2009
HGNC name MAX binding protein
HGNC id 7188
Location 17p13.3      Physical location : 2.287.354 - 2.304.258
Synonym name
  • Max-interacting protein
  • myc antagonist
  • protein ROX
  • Synonym symbol(s) MXI2, ROX, MAD6, MXD6, bHLHd3
    DNA
    TYPE functioning gene
    STRUCTURE 16.90 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure at 5' untranslated regions sequence containing an internal ribosome entry segment (IRES) essential for its function
    MAPPING cloned Y linked N status confirmed
    Physical map
    SKIP 17p13 olfactory receptor, family 1, subfamily D, member 5 PITPN 17p13.3 phosphotidylinositol transfer protein MGC34680 17p13.3 hypothetical protein MGC34680 RILP 17p13.3 hypothetical protein MGC34680 SCARF1 17p13.3 scavenger receptor class F, member 1 PRPF8 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast) LOC388317 17 LOC388317 MGC14376 17p13.3 hypothetical protein MGC14376 LOC388318 17 LOC388318 FLJ33817 17p13.3 hypothetical protein FLJ33817 SERPINF2 17p13 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 SERPINF1 17p13.3 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 KIAA1936 17p13.3 KIAA1936 protein RPA1 17p13.3 replication protein A1, 70kDa NGRH2 LOC388319 17 LOC388319 DPH2L1 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) OVCA2 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) HIC1 17p13.3 hypermethylated in cancer 1 C17orf31 17p13.3 chromosome 17 open reading frame 31 SRR 17q13.3 serine racemase LOC388320 17 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FLJ10534 17p13.3 hypothetical protein FLJ10534 KIAA0397 17p13.3 hypothetical protein FLJ10534 MNT 17p13.3 MAX binding protein MGC3329 17p13.3 hypothetical protein MGC3329 LOC390755 17 similar to eukaryotic translation initiation factor 4A1; initiation factor eIF-4A long form PAFAH1B1 17p13.3 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa KIAA0664 17q13.3 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa LOC388321 17 similar to Rap1 GTPase-activating protein 1 (Rap1GAP) OR1D5 17p13.3 olfactory receptor, family 1, subfamily D, member 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4865 - 582 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text restricted to embryonic tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two highly conserved domains, Sin3-interacting domain (SID)
  • and basic helix-loop-helix leucine zipper domain (bHLHzip), which are essential for the function during molecular switching from proliferation to differentiation (Guo 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • Myc/Mad family of transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor, potentially involved in proliferation and differentiation
  • antagonize the function of MYC
  • switch from MNT to MYC during bile duct ligation is responsible for the induction in TP53 and cyclin D1 expression and contributes to apoptosis (
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA as an homodimer or a heterodimer with MAX
    RNA
    small molecule
    protein
  • Max interactor 2 (interacting with Max to bind Myc-Max recognition sites)
  • MYC and MNT use MAX as a cofactor for DNA binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in acute leukaemia (Guo 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS