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FLASH GENE
Symbol MN1 contributors: mct/npt - updated : 09-03-2009
HGNC name meningioma (disrupted in balanced translocation) 1
HGNC id 7180
Corresponding disease
MN1 meningioma 1, familial
Location 22q12.1      Physical location : 28.144.265 - 28.197.486
Synonym name
  • meningioma chromosome region
  • probable tumor suppressor protein MN1
  • bK437G10B.1 (meningioma (disrupted in balanced translocation) 1)
  • Synonym symbol(s) MGCR1, MGCR, MGCR1-PEN, dJ353E16.2
    DNA
    TYPE functioning gene
    STRUCTURE 53.22 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure a CACCC-containing sequence, located 140 bp upstream of the transcription start site of the promoter, is required for MN1 action (Meester-Smoor 2007)
    MAPPING cloned Y linked N status provisional
    Physical map
    SEZ6L 22q11.21-q12.2 seizure related 6 homolog (mouse)-like FLJ38343 22q12.1 hypothetical protein FLJ38343 LOC391324 22 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC57168 22q12.1 similar to aspartate beta hydroxylase (ASPH) HPS4 22q11.2-q12.2 Hermansky-Pudlak syndrome 4 TFIP11 22q12.1 tuftelin interacting protein 11 TPST2 22q12.1 tyrosylprotein sulfotransferase 2 HMG1L10 22q12.1 high-mobility group (nonhistone chromosomal) protein 1-like 10 CRYBB1 22q11.22 crystallin, beta B1 CRYBA4 22q12.1 crystallin, beta A4 LOC391325 22 similar to HESB like domain containing 1 LOC388888 22 LOC388888 LOC388889 22 LOC388889 MN1 22q12.1 meningioma (disrupted in balanced translocation) 1 PITPNB 22q12.1 phosphotidylinositol transfer protein, beta KIAA1043 22q12.1 KIAA1043 protein LOC284901 22q12.2 similar to bA436C9.2 (PUTATIVE novel protein similar to part of HSP70/HSP90 organizing protein and transformation sensitive protein) CHEK2 22q12.1 CHK2 checkpoint homolog (S. pombe) HSC20 22q12.2 J-type co-chaperone HSC20 FLJ33814 22q12.2 hypothetical protein FLJ33814 XBP1 22q12.2 X-box binding protein 1 LOC388890 22 LOC388890 FLJ12747 22q12.1 novel C3HC4 type Zinc finger (ring finger) HS747E2A 22q12.1 hypothetical protein HS747E2A KREMEN1 22q12.1 kringle containing transmembrane protein 1 EMU1 22q12.2 emilin and multimerin-domain containing protein 1 C22orf3 22q12.1-q12.2 chromosome 22 open reading frame 3 EWSR1 22q12.2 Ewing sarcoma breakpoint region 1 GAS2L1 22q12.2 growth arrest-specific 2 like 1 RRP22 22q12.2 growth arrest-specific 2 like 1 AP1B1 22q12.2 adaptor-related protein complex 1, beta 1 subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 7569 136 1320 - Lekanne Deprez (1995)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple transcription activating domains
  • HOMOLOGY
    interspecies homolog to C.elegans F13D12.4
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be playing a role in tumor suppression
  • activates the transcription activity of the moloney sarcoma virus long terminal repeat, indicating that this protein itself may act as a transcription factor (Van Wely 2003)
  • may stimulate RAR/RXR-mediated transcription through interaction with EP300 (Van Wely 2003)
  • transcriptional co-activator and oncoprotein which activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence (Meester-Smoor 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MN1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    MN1TEL, a leukemia-related fusion protein containing parts of the MN1 and TEL (ETV6) genes (Meester-Smoor 2007)
    tumoral     --over  
    in certain types of human acute myeloid leukemia (Grosveld 2007)
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS