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FLASH GENE
Symbol MMP7 contributors: mct/pgu - updated : 20-03-2015
HGNC name matrix metallopeptidase 7 (matrilysin, uterine)
HGNC id 7174
Location 11q22.2      Physical location : 102.391.239 - 102.401.478
Synonym name
  • matrix metalloproteinase 7 (matrilysin, uterine)
  • matrin/uterine matrilysin
  • uterine metalloproteinase
    • Synonym symbol(s) MPSL1, PUMP1, MMP-7, Matrin
    EC.number 3.4.24.23
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text member of the MMP cluster
    STRUCTURE 10.24 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1147 - 267 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivefemale systemuterus  highly
     female systembreastmammary gland highly
     male systemprostate  lowly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    skin tegumentdermis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • a prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc-binding site and lacking the hemopexin-like (PEX) C terminal domain
    • conjugated HemoP , MetalloP
    isoforms Precursor pro-form consists of only a propeptide and a catalytic domain and lacks the C-terminal hemopexin-like domain (.PMID: 18955490)
    HOMOLOGY
    Homologene
    FAMILY
  • zinc dependent endopeptidases family
  • stromelysin subclass of MMP family
  • peptidase M10A family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein, extracellular matrix
    basic FUNCTION
  • regulator of matrix remodeling and mediator of pulmonary fibrosis (and potential therapeutic target)
  • generating angiostatin fragments by hydrolyzing plasminogen
  • may be responsible for the activation of prodefensins and thereby participating in innate host defense
  • remodeling of elastotic areas in sun damaged skin
  • required for the activation of defensin in small bowel
  • processes cell surface molecules such as pro-alpha-defensin, fas-ligand, pro-tumor necrosis factor alpha, E-cadherin
  • involved in adipocyte differentiation, enhanced collagen affinity, increased bioavailability of TGF beta, disrupted cell aggregation and increased cell invasion anf Fas-receptor-mediated apoptosis
  • degrades casein, gelatins of type I, III, IV, V, fibronectin and elastin
  • activating procollagenase
  • involved in wound healing
  • may regulate the activity of defensins in intestinal mucosa
  • potent modulator of synaptic vesicle recycling and synaptic ultrastructure and elevated levels of the enzyme, as may occur with brain inflammation, may adversely influence neurotransmission
  • involved in tumor angiogenesis, thereby contributing to malignant growth and hence associated with decreased survival
  • may be involved in the aging process of human mammary epithelial cells by affecting extracellular remodeling and intracellular signaling pathways
  • LAMB3, LAMC2, in conjunction with MMP7, play a key role in the progression of biliary tract cancer
  • is involved in the cleavage of CDH2 and modulates vascular smooth muscle cell (VSMC) apoptosis, and may therefore contribute to plaque development and rupture
  • new role for MMP7 in attenuating ciliated cell differentiation during wound repair
    • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    nucleotide, repair
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • binding two ions calcium Ca2+ per subunit
  • binding two ions zinc Zn2+ per subunit
    • protein
  • colocalizing and regulating DEFA5
  • interaction with ETS1 (contribution to the progression of HCC)
  • HAS2, HAS3 and HA may mediate cellular invasion via changes in MMP7 expression
  • binding TIMPs in a 1:1 stoechiometry
  • directly interacts with SDC2
  • MSLN enhances ovarian cancer invasion by MMP7 expression through the MAPK/ERK and JNK signal transduction pathways
  • MMP7 inhibition of BMP7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal dysplasia
  • is a key downstream effector of FOXC1-mediated invasiveness in breast cancer
  • MMP7 is a target gene of EPCAM signalling via EpICD nuclear translocation
  • MMP7 is a bona fide ETV1 target gene, implicating that MMP7 upregulation is partially responsible for the oncogenic effects of ETV1 in the prostate
  • in the small intestine, MMP7 is responsible for activating DEFAs, which are broad-spectrum anti-microbial peptides produced by the Paneth cells
  • functions to degrade extracellular matrix and other pericellular substrates including the adherens junction protein CDH1 to promote wound healing and tissue remodeling
  • regulator of CTNNB1 function in injured lung epithelium and may link extracellular proteolytic activity to cell junction disassembly and intracellular signaling
    • cell & other
  • binding of MMP7 to cell surface cholesterol sulfate (CS) is essential for the cell membrane-associated proteolytic action of the protease
    • REGULATION
    activated by proteinases and plasmin
    binding of sulfated glycosaminoglycans, such as heparin, chondroitin-4,6-sulfate or dermatan sulfate
    inhibited by TIMPs and TFPI2
    binding a catalytic zinc ion
    Other regulated by beta catenin/CF4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    with ETS1 in hepatocellular carcinomas
    tumoral     --over  
    in colorectal cancer with metastasis
    tumoral       gain of function
    differentially up-regulated in germ cells teratomas
    constitutional     --over  
    in epithelium by bacterial infection, inflammation and fibrosis
    constitutional     --over  
    in congenital renal dysplasia (RD)
    Susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma
    Variant & Polymorphism SNP , other
  • polymorphism in the promoter increasing susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma
  • snp Gly137Asp confers risk of liver cirrhosis
  • functional variants of MMP7 are associated with susceptibility to H.pylori-induced precancerous gastric lesions
    • Candidate gene
  • positive expression may serve as a predictor of lymph node metastasis in gastric cancer
  • elevated expression is predictor of disease recurrence of colon cancer and is related to decreased survival
  • higher expression of MMP7 supports the notion of a role in the growth of lung carcinoma
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    develop MMP7-targeted novel anti-cancer drugs that block specifically the membrane-associated proteolytic action of this MMP, thereby having restricted side effects
    cancerreproductivebreast
    may be a useful therapeutic target for treatment of this disease
    ANIMAL & CELL MODELS
  • Paneth cells (in mice)
  • MMP7(-/-) mice are resistant to LPS-induced lethality and that this resistance is correlated with reduced levels of systemic cytokines