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FLASH GENE
Symbol MMP27 contributors: - updated : 04-05-2004
HGNC name matrix metalloproteinase 27
HGNC id 14250
Location 11q24      Physical location : 102.562.414 - 102.576.468
Synonym symbol(s) MMP-27
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ANGPTL5 11q22.2 angiopoietin-like 5 MGC13040 11q22.2 hypothetical protein MGC13040 YAP1 11q13 Yes-associated protein 1, 65kDa LOC120318 11q22.2 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) BIRC3 11q25 baculoviral IAP repeat-containing 3 BIRC2 11q22 baculoviral IAP repeat-containing 2 PORIMIN 11q22.1 Homo sapiens pro-oncosis receptor inducing membrane injury gene (PORIMIN), mRNA. MMP7 11q22.2-q22.3 matrix metalloproteinase 7 (matrilysin, uterine) MMP20 11q22.2-q22.3 matrix metalloproteinase 20 (enamelysin) MMP27 11q24 matrix metalloproteinase 27 MMP8 11q22.2-q22.3 matrix metalloproteinase 8 (neutrophil collagenase) LOC390248 11 similar to matrix metalloproteinase 1 precursor MMP10 11q22.2-q22.3 matrix metalloproteinase 10 (stromelysin 2) MMP1 11q22.2-q22.3 matrix metalloproteinase 1 (interstitial collagenase) LOC120321 11q22.2 similar to casein kinase 1, alpha 1 MMP3 11q22.2-q22.3 matrix metalloproteinase 3 (stromelysin 1, progelatinase) MMP12 11q22.3 matrix metalloproteinase 12 (macrophage elastase) MMP13 11q22.2-q22.3 matrix metalloproteinase 13 (collagenase 3) MGC2714 11q22.2 hypothetical protein MGC2714 DNCH2 11q21-q22.1 dynein, cytoplasmic, heavy polypeptide 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a prodomain
  • a catalytic domain with Zn+ binding motif
  • an hemoplexin-like domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY matrix metalloproteinase (MMP) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION involved in proteolysis and peptidolysis by metallo-endopeptidase activity
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS