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FLASH GENE
Symbol MMP25 contributors: mct - updated : 04-09-2017
HGNC name matrix metalloproteinase 25
HGNC id 14246
Location 16p13.3      Physical location : 3.096.681 - 3.110.722
Synonym name
  • leukolysin
  • matrix metalloproteinase 20
  • matrix metalloproteinase-like 1
  • membrane-type 6 matrix metalloproteinase
    • Synonym symbol(s) MT6-MMP, MMP20, MMPL1, MT-MMP6, MMP-25
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 14.04 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3565 63 562 - 2007 17513868
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    cell lineage
    cell lines highly in colon carcinoma, astrocytoma, glioblastoma and cancer tissues
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal prodomaine
  • a signal sequence
  • a catalytic domain (furin recognition domain)
  • a potential GPI-anchor domain
  • a C-terminal hemopexin-like domain
    • conjugated GlycoP , HemoP , MetalloP
    mono polymer homomer , dimer
    isoforms Precursor active form is 45 kDa, secreted inactive proprotein activated by cleavage by extracellular proteinases
    HOMOLOGY
    Homologene
    FAMILY
  • MMP family, membrane-type MMP subfamily
  • peptidase M10A family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • the proenzyme is localized to granules and enzyme is located in the membrane
  • MMP17 (MT4-MMP) and MMP25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family
  • associated with the lipid rafts
  • predominantly localized in cell-cell junction regions
  • associates with the lipid raft compartment of the plasma membrane using a GPI anchor
    • basic FUNCTION
  • activates MMP2 by cleavage
  • is able to cleave type IV collagen, gelatin, fibronectin and fibrin
  • unique role for the stem region of MMP25 in mediating disulfide-linked homodimerization, an event whose outcome imparts protease stability to the protein
  • involving in the breakdown of extracellular matrix in normal physiological processes
  • may facilitate tumor progression through its ability to activates progelatinase A
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS development , inflammation , respiration
    PATHWAY
    metabolism
    signaling
    a component
  • under non-reducing conditions is consistently detected as a major form of 120 kDa, likely representing dimeric enzyme complexes at the cell surface
  • upon reduction, is mostly found as a 57-kDa species
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
    • protein
  • binding TIMPs in a 1:1 stoechiometry
  • MMP25 is a proteinase responsible for FCGR3A downmodulation
    • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by clusterin, TIMPs and TFPI2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS