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FLASH GENE
Symbol MMP24 contributors: mct/npt - updated : 12-06-2010
HGNC name matrix metalloproteinase 24 (membrane-inserted)
HGNC id 7172
Location 20q11.22      Physical location : 33.814.538 - 33.864.804
Synonym name
  • membrane-type 5 matrix metalloproteinase
  • MT-MMP 5
  • Synonym symbol(s) MT5-MMP, MMP25, MT-MMP5
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 50.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR within intron 4
    MAPPING cloned Y linked N status confirmed
    Physical map
    NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84 FER1L4 20q11.21 fer-1-like 4 (C. elegans) RPL37P1 11q13 ribosomal protein L37 pseudogene 1 LOC375095 20q11.23 similar to dJ309K20.1.1 (novel protein similar to dysferlin, isoform 1) SPAG4 20q11.2 sperm associated antigen 4 CPNE1 20q11.21 copine I RBM12 20q11.21 RNA binding motif protein 12 NFS1 20q11-q12 NFS1 nitrogen fixation 1 (S. cerevisiae) C20orf52 20q11.23 chromosome 20 open reading frame 52 RNPC2 20q11.21 RNA-binding region (RNP1, RRM) containing 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4344 - 645 - Goetje (2007)
    - - 1779 - 593 in the neurons and in the hippocampus Ross (2007)
  • also called MT5-MMP var
  • characterized by a 162 bp deletion within the signal and propeptide domains
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Nervousgangliasensory gangliadorsal root highly
     nervecranial nerve  highly
    Reproductivefemale systemuterus  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a prodomain (activation locus)
  • a zinc binding site in the catalytic domain
  • an hemopexin domain
  • a C terminal extension rich in hydrophobic residues characteristic of MT-MMPs, representing a putative transmembrane segment, the EWV motif
  • a cytoplasmic domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • matrix metalloproteinase (MMP) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text with a membrane type form
    basic FUNCTION
  • matrix metalloproteinase
  • pancreas and lung activator of MMP2
  • involved in neurogenesis
  • playing a role in the formation of endometriosis
  • essential mediator of peripheral thermal nociception and inflammatory hyperalgesia (Folgueras 2009)
  • plays an important role in cell-cell interactions between nociceptive neurites and mast cells (Folgueras 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding TIMPs in a 1:1 stoichiometry
  • N-cadherin is a substrate of MMP24 (Folgueras 2009)
  • cell & other
    REGULATION
    activated by furin( intracellularly) and proteinase
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in brain tumors
    constitutional     --over  
    in most peritoneal endometriosis lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions (Folgueras 2009)