| protein
| CSF2 |
|
binding TIMPs in a 1:1 stoechiometry |
|
WISP1 interacting with MMP2 (increased the migration and expression of MMP2 in human chondrosarcoma cells) ( |
|
 |
|
UTS2 and NOX4 stimulated FOXO2, FOXO3 activity and MMP2 is a target gene of FOXO3 |
|
S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a TP53-dependent manner |
|
novel regulatory mechanism for pro-MMP2 activation that is modulated through homodimerization of MMP2 |
|
BEX2 promoted the progression of glioma by promoting cell migration and invasion, and these effects might be mediated by CDH2 and MMP2 |
|
TACR1 was a potential regulator of human glioma cell migration by the up-regulation of MMP2 and MMP14 |
|
physical association between PAK4 and MM2, suggesting the future therapeutic potential of PAK4/MMP2 dual targeting in glioma treatment |
|
MMP14 is an up-stream regulator for MMP2 and TIMP2 expression |
|
NFATC1 sequestering the SMAD3 prevents the proteasome mediated degradation of SKIL and SKIL has a role on the regulation of MMP2, MMP9 activity |
|
CAPN7 interacted with activator protein 2 (TFAP2A), an important transcription factor of MMP2 |
|
HDAC10 binds to the promoter regions of MMP2 and -9, deacetylates histones H3 and H4 in these regions, blocks the binding of RNA polymerase II, and consequently down-regulates MMP2 and -9 expression |
|
ID4 decreased MMP2 expression by a direct inhibitory interaction with TWIST1, a basic helix-loop-helix transcription factor known to increase MMP2 expression |
|
GKN1 inhibits cell invasion by downregulating MMP2 expression through the NFKB1 pathway |
|
INVS could upregulate the expression of CDH2, VIM, MMP2, and MMP9 |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in inflammatory bowel diseases, poly and dermatomyositis | | tumoral
|
|
| --over
|
| |
in prostate tumor and in malignant mesothelioma and in thymoma with poor prognosis | | tumoral
|
|
|
| gain of function
| |
in head and neck cancer (by CSF2) and in invasive glioma (inhibited by PTEN) | | tumoral
|
|
| --over
|
| |
in head and neck carcinoma with lymph node metastasis and in breast carcinoma with short survival | | constitutional
|
|
|
| loss of function
| |
linked with an autosomal recessive form of multicentric osteolysis | | constitutional
|
|
| --low
|
| |
contribute to the endothelial dysfunction that is central to the pathophysiology of preeclampsia | | constitutional
|
|
| --over
|
| |
in scarred keratoconic cornea | | tumoral
|
|
|
| gain of function
| |
in high expression of estrogen receptors associated with increased BCL2 levels in breast carcinoma | | constitutional
|
|
| --over
|
| |
have been detected after skin injury (jansen 2007) | | constitutional
|
|
| --over
|
| |
in women with pelvic organ prolapse (Connell 2008) | | tumoral
|
|
|
| gain of function
| |
resulting from decreased ID4 expression in glioblastoma multiforme (GBM), may contribute to the morbidity and mortality of GBM patients | | constitutional
|
|
|
| gain of function
| |
SPARC, MMP2 and MM9 were significantly up-regulated in intracranial aneurysms relative to the expression levels in the normal Circle of Willis arteries | |
