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FLASH GENE
Symbol MMP17 contributors: mct - updated : 29-11-2014
HGNC name matrix metalloproteinase 17 (membrane-inserted)
HGNC id 7163
Location 12q24.33      Physical location : 132.312.940 - 132.336.316
Synonym symbol(s) MT4MMP
EC.number 3.4.24.-
DNA
TYPE functioning gene
STRUCTURE 23.38 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • SNAI2 regulated the transcription of MMP17 through direct binding to the E-box located in its proximal promoter
  • MAPPING cloned Y linked   status confirmed
    regionally located linked to D12S367
    RNA
    TRANSCRIPTS type messenger
    text one minor non expressed transcript and a major alternatively spliced, 67 and 71kDa (Kajita)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2427 67 603 - 2003 12730128
    - - - 57.8 519 - 2003 12730128
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselcapillary  predominantly Homo sapiensFetal
    Nervousbrain   highly
    Reproductivefemale systemovary   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc binding site (the cysteine switch)
  • a hinge region
  • a furin activation sequence
  • a GPI anchor domain
  • conjugated GlycoP , MetalloP
    isoforms Precursor two forms 67 and 71kDa
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • MMP17 (MT4-MMP) and MMP25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family
  • basic FUNCTION
  • membrane type 4-matrix metalloproteinase
  • involved in neurogenesis
  • implicated in the control of articular cartilage extracellular matrix aggrecan integrity in an inflammatory environment
  • key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding TIMPs in a 1:1 stoechiometry
  • SNAI2 regulated the transcription of MMP17 through direct binding to the E-box located in its proximal promoter
  • implicated in the activation of one of the key aggrecanases: ADAMTS4
  • SERPINE2 inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells
  • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS