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FLASH GENE
Symbol MMP16 contributors: npt/ - updated : 04-05-2004
HGNC name matrix metalloproteinase 16 (membrane-inserted)
HGNC id 7162
Location 8q21.3      Physical location : 89.049.461 - 89.339.717
Synonym name
  • chromosome 8 open reading frame 57
  • membrane-type matrix metalloproteinase 3
    • Synonym symbol(s) MT3-MMP, MMP-X2, MT-MMP3, SM3, C8orf57, DKFZp761D112
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 290.26 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 6347 - 607 blood vessels Takino
    8 splicing 1800 - 457 ovary Takino
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc binding site (the cysteine switch)
  • a hinge region
  • a furin activation sequence
  • one hemopexin-like domain
  • a C terminal hydrophobic extension,representing a putative transmembrane segment
    • conjugated HemoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Mmp16
    Homologene
    FAMILY
  • peptidase M10A family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • endopeptidase degrading various components of the extracellular matrix
  • activates pro_MMP2
  • involved in the matrix remodeling of blood vessels
  • have a role in reduced cell adhesion and spreading
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • membrane constituent
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • ca2+
    • protein
  • binding TIMPs in a 1:1 stoechiometry
    • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with MMP2 in melanoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS