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FLASH GENE
Symbol MLYCD contributors: mct - updated : 24-04-2013
HGNC name malonyl-CoA decarboxylase
HGNC id 7150
Corresponding disease
MLYCD malonyl-CoA decarboxylase deficiency
Location 16q23.3      Physical location : 83.932.729 - 83.949.785
Synonym name
  • malonyl-CoA decarboxylase, mitochondrial
  • Synonym symbol(s) MCD
    EC.number 4.1.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 17.06 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2211 - 493 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region having no effect on the catalytic activity of the enzyme but playing a role in the folding process and conformation stability
  • C terminal peroxisomal targeting signal (PTS1) of serine, leucine
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • STARD4 and cytosolic MLYCD act similarly by increasing the rate of transfer of sterol to the endocytic recycling compartment and to the ER
  • basic FUNCTION
  • cytoplasmic regulation of malonyl-CoA and their of mitochondrial fatty acid uptake and oxidation
  • peroxisome degrading intraperoxisome malonyl-CoA generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acid
  • potentially participating in the regulation of cytosolic malonyl-CoA levels and of hepatic fatty acid oxidation
  • key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism
  • regulates fatty acid biosynthesis and converts malonyl-CoA to acetyl-CoA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLYCD
    related resource MLYCD Allelic Variant Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with the decreased expression of ACACA and PRKAB1 are important regulators of the maturation of fatty acid oxidation in the newborn heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    potential therapeutic targets for the treatment of hypoxic pulmonary vasoconstriction and pulmonary hypertension
    ANIMAL & CELL MODELS
  • mice lacking the gene Mcyld do not show pulmonary vasoconstriction during exposure to acute hypoxia and do not develop pulmonary arterial hypertension during chronic hypoxia but have an otherwise normal phenotype