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FLASH GENE
Symbol MLXIP contributors: npt - updated : 24-02-2005
HGNC name MLX interacting protein
HGNC id 17055
Location 12q21.31      Physical location : 122.516.759 - 122.628.965
Synonym name
  • Mlx interactor
  • transcriptional activator MondoA
  • Synonym symbol(s) MIR, KIAA0867, MONDOA
    DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     16 Exon(s)
    motif repetitive sequence   ALU
    text structure
  • an Alu sequence within the 3-prime untranslated region
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3540 39 379 - Merla, unpublished
  • 1 basic helix-loop-helix (bHLH) domain
  • - - 2760 101 919 - Billin, 2000
  • 1 basic helix-loop-helix (bHLH) domain
  • - splicing 4373 - 526 - Merla, unpublished
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  moderately
     liver   lowly
     mouthtongue  moderately
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   moderately
     spleen   highly
     thymus   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
    Respiratorylung   lowly
     respiratory tractlarynx  moderately
    Skin/Tegumentskin   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central serine-threonine-proline (STP)-rich domain
  • a basic helix-loop-helix domain
  • a zipper region
  • a C-terminal MLX homology domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • bHLHZip family of transcriptional regulators
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • the heterodimer shuttles between the cytoplasmic and nuclear compartments
  • basic FUNCTION
  • activating transcription from CACGTG E boxes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimers with MLX
  • INTERACTION
    DNA binding to CACGTG E boxes
    RNA
    small molecule
    protein
  • MLX
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS